Discovering modulators of gene expression

Özgün Babur, Emek Demir, Mithat Gönen, Chris Sander, Ugur Dogrusoz

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Proteins that modulate the activity of transcription factors, often called modulators, play a critical role in creating tissue- and context-specific gene expression responses to the signals cells receive. GEM (Gene Expression Modulation) is a probabilistic framework that predicts modulators, their affected targets and mode of action by combining gene expression profiles, protein-protein interactions and transcription factor-target relationships. Using GEM, we correctly predicted a significant number of androgen receptor modulators and observed that most modulators can both act as co-activators and co-repressors for different target genes.

Original languageEnglish (US)
Article numbergkq287
Pages (from-to)5648-5656
Number of pages9
JournalNucleic acids research
Volume38
Issue number17
DOIs
StatePublished - May 13 2010

ASJC Scopus subject areas

  • Genetics

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    Babur, Ö., Demir, E., Gönen, M., Sander, C., & Dogrusoz, U. (2010). Discovering modulators of gene expression. Nucleic acids research, 38(17), 5648-5656. [gkq287]. https://doi.org/10.1093/nar/gkq287