Discovering modulators of gene expression

Ozgun Babur, Emek Demir, Mithat Gönen, Chris Sander, Ugur Dogrusoz

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Proteins that modulate the activity of transcription factors, often called modulators, play a critical role in creating tissue- and context-specific gene expression responses to the signals cells receive. GEM (Gene Expression Modulation) is a probabilistic framework that predicts modulators, their affected targets and mode of action by combining gene expression profiles, protein-protein interactions and transcription factor-target relationships. Using GEM, we correctly predicted a significant number of androgen receptor modulators and observed that most modulators can both act as co-activators and co-repressors for different target genes.

Original languageEnglish (US)
Article numbergkq287
Pages (from-to)5648-5656
Number of pages9
JournalNucleic Acids Research
Volume38
Issue number17
DOIs
StatePublished - May 13 2010
Externally publishedYes

Fingerprint

Gene Expression
Transcription Factors
Co-Repressor Proteins
Proteins
Androgen Receptors
Transcriptome
Genes

ASJC Scopus subject areas

  • Genetics
  • Medicine(all)

Cite this

Babur, O., Demir, E., Gönen, M., Sander, C., & Dogrusoz, U. (2010). Discovering modulators of gene expression. Nucleic Acids Research, 38(17), 5648-5656. [gkq287]. https://doi.org/10.1093/nar/gkq287

Discovering modulators of gene expression. / Babur, Ozgun; Demir, Emek; Gönen, Mithat; Sander, Chris; Dogrusoz, Ugur.

In: Nucleic Acids Research, Vol. 38, No. 17, gkq287, 13.05.2010, p. 5648-5656.

Research output: Contribution to journalArticle

Babur, O, Demir, E, Gönen, M, Sander, C & Dogrusoz, U 2010, 'Discovering modulators of gene expression', Nucleic Acids Research, vol. 38, no. 17, gkq287, pp. 5648-5656. https://doi.org/10.1093/nar/gkq287
Babur O, Demir E, Gönen M, Sander C, Dogrusoz U. Discovering modulators of gene expression. Nucleic Acids Research. 2010 May 13;38(17):5648-5656. gkq287. https://doi.org/10.1093/nar/gkq287
Babur, Ozgun ; Demir, Emek ; Gönen, Mithat ; Sander, Chris ; Dogrusoz, Ugur. / Discovering modulators of gene expression. In: Nucleic Acids Research. 2010 ; Vol. 38, No. 17. pp. 5648-5656.
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