Discovering early molecular determinants of leukemogenesis

    Research output: Contribution to journalComment/debate

    10 Scopus citations


    Truncating mutations of the G-CSF receptor are found during disease course in nearly half of all patients with severe congenital neutropenia. In this issue of the JCI, Liu et al. demonstrate that these mutations confer a competitive clonal advantage upon HSCs in mice and that the advantage is conditional because it is observed only in the presence of the ligand G-CSF (see the related article beginning on page 946). Once activated, the mutant receptor requires the function of Stat5 in order to effect clonal expansion of this stem cell population. The results support the notion that early molecular steps in this and other neoplastic processes represent adaptations in which, through somatic mutations, "unfit" stem cells gain a measure of fitness by altering their relationships with their microenvironment.

    Original languageEnglish (US)
    Pages (from-to)847-850
    Number of pages4
    JournalJournal of Clinical Investigation
    Issue number3
    StatePublished - Mar 1 2008


    ASJC Scopus subject areas

    • Medicine(all)

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