Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse

Brenda J. Polster, Shawn K. Westaway, Thuy M. Nguyen, Moon Y. Yoon, Susan J. Hayflick

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

miR-103 and miR-107, microRNAs hosted by pantothenate kinase genes, are proposed to regulate cellular lipid metabolism. microRNA-mediated regulation is complex, potentially affecting expression of the host gene, related enzymes within the same pathway, or apparently distinct targets. Using qRT-PCR, we demonstrate that miR-103 and miR-107 expression does not correlate with expression of host pantothenate kinase genes in mouse tissues. The miR-103/7 family thus provides an intriguing model for dissecting microRNA transcription, processing and coordinated function within host genes.

Original languageEnglish (US)
Pages (from-to)292-295
Number of pages4
JournalMolecular Genetics and Metabolism
Volume101
Issue number2-3
DOIs
StatePublished - Oct 1 2010

Keywords

  • Intronic microRNA
  • Pantothenate kinase

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Endocrinology

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