Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse

Brenda J. Polster; Shawn K. Westaway; Thuy M. Nguyen; Moon Y. Yoon; Susan J. Hayflick

doi:10.1016/j.ymgme.2010.07.016

Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse

Brenda J. Polster, Shawn K. Westaway, Thuy M. Nguyen, Moon Y. Yoon, Susan J. Hayflick

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

miR-103 and miR-107, microRNAs hosted by pantothenate kinase genes, are proposed to regulate cellular lipid metabolism. microRNA-mediated regulation is complex, potentially affecting expression of the host gene, related enzymes within the same pathway, or apparently distinct targets. Using qRT-PCR, we demonstrate that miR-103 and miR-107 expression does not correlate with expression of host pantothenate kinase genes in mouse tissues. The miR-103/7 family thus provides an intriguing model for dissecting microRNA transcription, processing and coordinated function within host genes.

Original language	English (US)
Pages (from-to)	292-295
Number of pages	4
Journal	Molecular Genetics and Metabolism
Volume	101
Issue number	2-3
DOIs	https://doi.org/10.1016/j.ymgme.2010.07.016
State	Published - Oct 2010

Keywords

Intronic microRNA
Pantothenate kinase

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Biology
Genetics
Endocrinology

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10.1016/j.ymgme.2010.07.016

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title = "Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse",

abstract = "miR-103 and miR-107, microRNAs hosted by pantothenate kinase genes, are proposed to regulate cellular lipid metabolism. microRNA-mediated regulation is complex, potentially affecting expression of the host gene, related enzymes within the same pathway, or apparently distinct targets. Using qRT-PCR, we demonstrate that miR-103 and miR-107 expression does not correlate with expression of host pantothenate kinase genes in mouse tissues. The miR-103/7 family thus provides an intriguing model for dissecting microRNA transcription, processing and coordinated function within host genes.",

keywords = "Intronic microRNA, Pantothenate kinase",

author = "Polster, {Brenda J.} and Westaway, {Shawn K.} and Nguyen, {Thuy M.} and Yoon, {Moon Y.} and Hayflick, {Susan J.}",

note = "Funding Information: This work was supported by the Huebner Family Pediatric Neurobiology of Disease Fellowship (to B.P.). ",

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T1 - Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse

AU - Polster, Brenda J.

AU - Westaway, Shawn K.

AU - Nguyen, Thuy M.

AU - Yoon, Moon Y.

AU - Hayflick, Susan J.

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PY - 2010/10

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N2 - miR-103 and miR-107, microRNAs hosted by pantothenate kinase genes, are proposed to regulate cellular lipid metabolism. microRNA-mediated regulation is complex, potentially affecting expression of the host gene, related enzymes within the same pathway, or apparently distinct targets. Using qRT-PCR, we demonstrate that miR-103 and miR-107 expression does not correlate with expression of host pantothenate kinase genes in mouse tissues. The miR-103/7 family thus provides an intriguing model for dissecting microRNA transcription, processing and coordinated function within host genes.

AB - miR-103 and miR-107, microRNAs hosted by pantothenate kinase genes, are proposed to regulate cellular lipid metabolism. microRNA-mediated regulation is complex, potentially affecting expression of the host gene, related enzymes within the same pathway, or apparently distinct targets. Using qRT-PCR, we demonstrate that miR-103 and miR-107 expression does not correlate with expression of host pantothenate kinase genes in mouse tissues. The miR-103/7 family thus provides an intriguing model for dissecting microRNA transcription, processing and coordinated function within host genes.

KW - Intronic microRNA

KW - Pantothenate kinase

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Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse

Abstract

Keywords

ASJC Scopus subject areas

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