Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse

Brenda J. Polster, Shawn Westaway, Thuy M. Nguyen, Moon Y. Yoon, Susan Hayflick

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

miR-103 and miR-107, microRNAs hosted by pantothenate kinase genes, are proposed to regulate cellular lipid metabolism. microRNA-mediated regulation is complex, potentially affecting expression of the host gene, related enzymes within the same pathway, or apparently distinct targets. Using qRT-PCR, we demonstrate that miR-103 and miR-107 expression does not correlate with expression of host pantothenate kinase genes in mouse tissues. The miR-103/7 family thus provides an intriguing model for dissecting microRNA transcription, processing and coordinated function within host genes.

Original languageEnglish (US)
Pages (from-to)292-295
Number of pages4
JournalMolecular Genetics and Metabolism
Volume101
Issue number2-3
DOIs
StatePublished - Oct 2010

Fingerprint

MicroRNAs
Genes
Lipid Metabolism
Transcription
Gene Expression
Polymerase Chain Reaction
Enzymes
Tissue
pantothenate kinase
Processing

Keywords

  • Intronic microRNA
  • Pantothenate kinase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse. / Polster, Brenda J.; Westaway, Shawn; Nguyen, Thuy M.; Yoon, Moon Y.; Hayflick, Susan.

In: Molecular Genetics and Metabolism, Vol. 101, No. 2-3, 10.2010, p. 292-295.

Research output: Contribution to journalArticle

Polster, Brenda J. ; Westaway, Shawn ; Nguyen, Thuy M. ; Yoon, Moon Y. ; Hayflick, Susan. / Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse. In: Molecular Genetics and Metabolism. 2010 ; Vol. 101, No. 2-3. pp. 292-295.
@article{d98362e62f37444392bbcab4dea52ce2,
title = "Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse",
abstract = "miR-103 and miR-107, microRNAs hosted by pantothenate kinase genes, are proposed to regulate cellular lipid metabolism. microRNA-mediated regulation is complex, potentially affecting expression of the host gene, related enzymes within the same pathway, or apparently distinct targets. Using qRT-PCR, we demonstrate that miR-103 and miR-107 expression does not correlate with expression of host pantothenate kinase genes in mouse tissues. The miR-103/7 family thus provides an intriguing model for dissecting microRNA transcription, processing and coordinated function within host genes.",
keywords = "Intronic microRNA, Pantothenate kinase",
author = "Polster, {Brenda J.} and Shawn Westaway and Nguyen, {Thuy M.} and Yoon, {Moon Y.} and Susan Hayflick",
year = "2010",
month = "10",
doi = "10.1016/j.ymgme.2010.07.016",
language = "English (US)",
volume = "101",
pages = "292--295",
journal = "Molecular Genetics and Metabolism",
issn = "1096-7192",
publisher = "Academic Press Inc.",
number = "2-3",

}

TY - JOUR

T1 - Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse

AU - Polster, Brenda J.

AU - Westaway, Shawn

AU - Nguyen, Thuy M.

AU - Yoon, Moon Y.

AU - Hayflick, Susan

PY - 2010/10

Y1 - 2010/10

N2 - miR-103 and miR-107, microRNAs hosted by pantothenate kinase genes, are proposed to regulate cellular lipid metabolism. microRNA-mediated regulation is complex, potentially affecting expression of the host gene, related enzymes within the same pathway, or apparently distinct targets. Using qRT-PCR, we demonstrate that miR-103 and miR-107 expression does not correlate with expression of host pantothenate kinase genes in mouse tissues. The miR-103/7 family thus provides an intriguing model for dissecting microRNA transcription, processing and coordinated function within host genes.

AB - miR-103 and miR-107, microRNAs hosted by pantothenate kinase genes, are proposed to regulate cellular lipid metabolism. microRNA-mediated regulation is complex, potentially affecting expression of the host gene, related enzymes within the same pathway, or apparently distinct targets. Using qRT-PCR, we demonstrate that miR-103 and miR-107 expression does not correlate with expression of host pantothenate kinase genes in mouse tissues. The miR-103/7 family thus provides an intriguing model for dissecting microRNA transcription, processing and coordinated function within host genes.

KW - Intronic microRNA

KW - Pantothenate kinase

UR - http://www.scopus.com/inward/record.url?scp=77957226687&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957226687&partnerID=8YFLogxK

U2 - 10.1016/j.ymgme.2010.07.016

DO - 10.1016/j.ymgme.2010.07.016

M3 - Article

VL - 101

SP - 292

EP - 295

JO - Molecular Genetics and Metabolism

JF - Molecular Genetics and Metabolism

SN - 1096-7192

IS - 2-3

ER -