Discordant expression of CD3 and T-cell receptor beta-chain antigens in T-lineage lymphomas

Louis Picker, M. B. Brenner, L. M. Weiss, S. D. Smith, R. A. Warnke

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Using an immunoperoxidase technique that identifies both surface and cytoplasmic antigen expression, the authors examined 28 benign reactive lymphoproliferative lesions and 55 T-lineage lymphomas for reactivity with CD3 (Leu-4; T-cell receptor-associated antigen) and βF1 antibodies, the latter recognizing nonpolymorphic determinants on T-cell receptor beta chains. Consistent with previous observations that these two antigens are co-expressed on the vast majority of thymocytes, peripheral blood T cells and tonsillar T cells, all 28 reactive lymphoproliferations showed essentially identical patterns of CD3 and βF1 expression. In contrast, only 29 of 55 T-lineage lymphomas displayed coexpression of these antigens. Among 33 peripheral T-cell lymphomas, 11 cases showed CD3/βF1 discordance (7 CD3+/βF1-; 4 CD3-/βF1+), and 5 showed absence of both these antigens. Nine of 22 T-lymphoblastic lymphomas showed CD3/βF1 discordance (all CD3+/βF1-), and 1 case was CD3-/βF1-. These patterns of CD3/βF1 expression, along with the patterns of CD2, CD4, CD5, CD7, and CD8 antigen expression in these neoplasms, indicate that T-cell lymphomas can manifest phenotypes not apparently reflective of normal T populations and suggest the presence of abnormal gene expression in these malignancies. The existence of aberrant phenotypes in T-cell neoplasia suggests caution in interpretation of investigations using T-lineage malignancies as models of normal T-cell biology. Finally, the identification of phenotypic abnormalities in T-lineage populations can be of great diagnostic usefulness in the delineation of benign versus malignant T-cell proliferations.

Original languageEnglish (US)
Pages (from-to)434-440
Number of pages7
JournalAmerican Journal of Pathology
Volume129
Issue number3
StatePublished - 1987
Externally publishedYes

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Antigen Receptors, T-Cell, alpha-beta
Lymphoma
T-Lymphocytes
Antigens
CD7 Antigens
CD2 Antigens
Neoplasms
CD5 Antigens
Peripheral T-Cell Lymphoma
CD8 Antigens
Phenotype
CD4 Antigens
T-Cell Lymphoma
Thymocytes
Surface Antigens
T-Cell Antigen Receptor
Immunoenzyme Techniques
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Population
Cell Biology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Picker, L., Brenner, M. B., Weiss, L. M., Smith, S. D., & Warnke, R. A. (1987). Discordant expression of CD3 and T-cell receptor beta-chain antigens in T-lineage lymphomas. American Journal of Pathology, 129(3), 434-440.

Discordant expression of CD3 and T-cell receptor beta-chain antigens in T-lineage lymphomas. / Picker, Louis; Brenner, M. B.; Weiss, L. M.; Smith, S. D.; Warnke, R. A.

In: American Journal of Pathology, Vol. 129, No. 3, 1987, p. 434-440.

Research output: Contribution to journalArticle

Picker, L, Brenner, MB, Weiss, LM, Smith, SD & Warnke, RA 1987, 'Discordant expression of CD3 and T-cell receptor beta-chain antigens in T-lineage lymphomas', American Journal of Pathology, vol. 129, no. 3, pp. 434-440.
Picker, Louis ; Brenner, M. B. ; Weiss, L. M. ; Smith, S. D. ; Warnke, R. A. / Discordant expression of CD3 and T-cell receptor beta-chain antigens in T-lineage lymphomas. In: American Journal of Pathology. 1987 ; Vol. 129, No. 3. pp. 434-440.
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