Abstract
Purified porcine carotid elastin is under development as a substrate for a vascular conduit. The permeability of the graft may have implications in recellularization. Light and scanning electron microscopy indicate that the lumen and adventitial surfaces have unique extracellular matrix morphology. This study investigates the permeability of the material, with consideration of the direction of the flow. The permeability of the adventitial surface was found to be approximately twice that of the lumenal surface. The mean permeability was 0.0123 ± 0.005 mL/min*cm2 for flow through from lumen surface to the adventitial surface and 0.0310 ± 0.007 mL/min*cm2 for flow through the adventitial surface to the lumen surface. The difference in elastin architecture can be taken advantage of to optimize recellularization in vitrio and in vivo This is only the second biomaterial to have this described behavior.
Original language | English (US) |
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Pages (from-to) | 413-414 |
Number of pages | 2 |
Journal | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
Volume | 1 |
State | Published - 2002 |
Event | Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States Duration: Oct 23 2002 → Oct 26 2002 |
Keywords
- Elastin
- Permeability
- Vascular
ASJC Scopus subject areas
- Signal Processing
- Biomedical Engineering
- Computer Vision and Pattern Recognition
- Health Informatics