Directional permeability in a porcine carotid elastin biomaterial vascular conduit. 2nd joint conference of the IEEE engineering in medicine and biology society and the biomedical engineering society

A. D. Janis, K. A. Lagerquist, M. T. Hinds

Research output: Contribution to journalConference article

Abstract

Purified porcine carotid elastin is under development as a substrate for a vascular conduit. The permeability of the graft may have implications in recellularization. Light and scanning electron microscopy indicate that the lumen and adventitial surfaces have unique extracellular matrix morphology. This study investigates the permeability of the material, with consideration of the direction of the flow. The permeability of the adventitial surface was found to be approximately twice that of the lumenal surface. The mean permeability was 0.0123 ± 0.005 mL/min*cm2 for flow through from lumen surface to the adventitial surface and 0.0310 ± 0.007 mL/min*cm2 for flow through the adventitial surface to the lumen surface. The difference in elastin architecture can be taken advantage of to optimize recellularization in vitrio and in vivo This is only the second biomaterial to have this described behavior.

Original languageEnglish (US)
Pages (from-to)413-414
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
StatePublished - Dec 1 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Keywords

  • Elastin
  • Permeability
  • Vascular

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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