Directional excitatory input to direction-selective ganglion cells in the rabbit retina

Kumiko A. Percival, Sowmya Venkataramani, Robert G. Smith, William Taylor

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Directional responses in retinal ganglion cells are generated in large part by direction-selective release of γ-aminobutyric acid from starburst amacrine cells onto direction-selective ganglion cells (DSGCs). The excitatory inputs to DSGCs are also widely reported to be direction-selective, however, recent evidence suggests that glutamate release from bipolar cells is not directional, and directional excitation seen in patch-clamp analyses may be an artifact resulting from incomplete voltage control. Here, we test this voltage-clamp-artifact hypothesis in recordings from 62 ON-OFF DSGCs in the rabbit retina. The strength of the directional excitatory signal varies considerably across the sample of cells, but is not correlated with the strength of directional inhibition, as required for a voltage-clamp artifact. These results implicate additional mechanisms in generating directional excitatory inputs to DSGCs.

Original languageEnglish (US)
JournalJournal of Comparative Neurology
DOIs
StateAccepted/In press - 2017

Fingerprint

Ganglia
Retina
Rabbits
Artifacts
Aminobutyrates
Amacrine Cells
Retinal Ganglion Cells
Direction compound
Glutamic Acid

Keywords

  • Amacrine cells
  • Direction selective
  • Excitation
  • Inhibition
  • Rabbit
  • Retinal ganglion cell
  • RRID:SCR_000325
  • Synaptic transmission
  • Voltage clamp

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Directional excitatory input to direction-selective ganglion cells in the rabbit retina. / Percival, Kumiko A.; Venkataramani, Sowmya; Smith, Robert G.; Taylor, William.

In: Journal of Comparative Neurology, 2017.

Research output: Contribution to journalArticle

Percival, Kumiko A. ; Venkataramani, Sowmya ; Smith, Robert G. ; Taylor, William. / Directional excitatory input to direction-selective ganglion cells in the rabbit retina. In: Journal of Comparative Neurology. 2017.
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