Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors

Jeffrey B. Wyckoff, Yarong Wang, Elaine Y. Lin, Jiu Feng Li, Sumanta Goswami, E. Richard Stanley, Jeffrey E. Segall, Jeffrey W. Pollard, John Condeelis

Research output: Contribution to journalArticlepeer-review

828 Scopus citations

Abstract

Although the presence of macrophages in tumors has been correlated with poor prognosis, until now there was no direct observation of how macrophages are involved in hematogenous metastasis. In this study, we use multiphoton microscopy to show, for the first time, that tumor cell intravasation occurs in association with perivascular macrophages in mammary tumors. Furthermore, we show that perivascular macrophages of the mammary tumor are associated with tumor cell intravasation in the absence of local angiogenesis. These results show that the interaction between macrophages and tumor cells lying in close proximity defines a microenvironment that is directly involved in the intravasation of cancer cells in mammary tumors.

Original languageEnglish (US)
Pages (from-to)2649-2656
Number of pages8
JournalCancer Research
Volume67
Issue number6
DOIs
StatePublished - Mar 15 2007
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors'. Together they form a unique fingerprint.

Cite this