Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor

Gobinda Sarkar, Stephen Kapelner, David K. Grandy, Mark Marchionni, Olivier Civelli, Janet Sobell, Leonard Heston, Steve S. Sommer

    Research output: Contribution to journalArticle

    100 Scopus citations

    Abstract

    The dopamine D2 receptor gene (gene symbol DRD2) is a candidate gene for schizophrenia because the potency of certain neuroleptics correlates with their affinity for this receptor. Seven regions of likely functional significance including the coding sequences and the splice junctions were fully sequenced in the dopamine D2 receptor of 14 schizophrenics (and partially in several others) meeting DSM-III-R diagnostic criteria and in four unaffected non-Caucasians (97 kb of total sequence). No structural changes were found, suggesting that alteration in the structure of the dopamine D2 receptor is not commonly involved in the etiology of schizophrenia. However, two common and one uncommon intragenic polymorphisms were found. At least one of the polymorphisms was informative for linkage in 70% of Caucasians and 78% of Koreans.

    Original languageEnglish (US)
    Pages (from-to)8-14
    Number of pages7
    JournalGenomics
    Volume11
    Issue number1
    DOIs
    StatePublished - Sep 1991

    ASJC Scopus subject areas

    • Genetics

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    Sarkar, G., Kapelner, S., Grandy, D. K., Marchionni, M., Civelli, O., Sobell, J., Heston, L., & Sommer, S. S. (1991). Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor. Genomics, 11(1), 8-14. https://doi.org/10.1016/0888-7543(91)90096-W