Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors

Hisashi Arase; Edward S. Mocarski; Ann E. Campbell; Ann B. Hill; Lewis L. Lanier

doi:10.1126/science.1070884

Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors

Hisashi Arase, Edward S. Mocarski, Ann E. Campbell, Ann B. Hill, Lewis L. Lanier

Research output: Contribution to journal › Article › peer-review

1003 Scopus citations

Abstract

Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I antigens, preventing attack against healthy cells. House cytomegalovirus (MCMV) encodes an MHC-like protein (m157) that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice. In MCMV-resistant mice, this viral protein engages a related activating receptor (Ly49H) and confers host protection. These activating and inhibitory receptors are highly homologous, suggesting the possibility that one evolved from the other in response to selective pressure imposed by the pathogen.

Original language	English (US)
Pages (from-to)	1323-1326
Number of pages	4
Journal	Science
Volume	296
Issue number	5571
DOIs	https://doi.org/10.1126/science.1070884
State	Published - May 17 2002
Externally published	Yes

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title = "Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors",

abstract = "Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I antigens, preventing attack against healthy cells. House cytomegalovirus (MCMV) encodes an MHC-like protein (m157) that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice. In MCMV-resistant mice, this viral protein engages a related activating receptor (Ly49H) and confers host protection. These activating and inhibitory receptors are highly homologous, suggesting the possibility that one evolved from the other in response to selective pressure imposed by the pathogen.",

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AU - Arase, Hisashi

AU - Mocarski, Edward S.

AU - Campbell, Ann E.

AU - Hill, Ann B.

AU - Lanier, Lewis L.

PY - 2002/5/17

Y1 - 2002/5/17

N2 - Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I antigens, preventing attack against healthy cells. House cytomegalovirus (MCMV) encodes an MHC-like protein (m157) that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice. In MCMV-resistant mice, this viral protein engages a related activating receptor (Ly49H) and confers host protection. These activating and inhibitory receptors are highly homologous, suggesting the possibility that one evolved from the other in response to selective pressure imposed by the pathogen.

AB - Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I antigens, preventing attack against healthy cells. House cytomegalovirus (MCMV) encodes an MHC-like protein (m157) that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice. In MCMV-resistant mice, this viral protein engages a related activating receptor (Ly49H) and confers host protection. These activating and inhibitory receptors are highly homologous, suggesting the possibility that one evolved from the other in response to selective pressure imposed by the pathogen.

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JF - Science

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ER -

Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors

Abstract

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