Direct Oral Anticoagulant Use: A Practical Guide to Common Clinical Challenges

Ashley Chen, Eric Stecker, Bruce A Warden

    Research output: Contribution to journalReview articlepeer-review

    12 Scopus citations

    Abstract

    Direct oral anticoagulants (DOACs) have quickly become attractive alternatives to the long-standing standard of care in anticoagulation, vitamin K antagonist. DOACs are indicated for prevention and treatment of several cardiovascular conditions. Since the first approval in 2010, DOACs have emerged as leading therapeutic alternatives that provide both clinicians and patients with more effective, safe, and convenient treatment options in thromboembolic settings. With the expanding role of DOACs, clinicians are faced with increasingly complex decisions relating to appropriate agent, duration of treatment, and use in special populations. This review will provide an overview of DOACs and act as a practical reference for clinicians to optimize DOAC use among common challenging scenarios. Topics addressed include (1) appropriate indications; (2) use in patients with specific comorbidities; (3) monitoring parameters; (4) transitioning between anticoagulant regimens; (5) major drug interactions; and (6) cost considerations.

    Original languageEnglish (US)
    Pages (from-to)e017559
    JournalJournal of the American Heart Association
    Volume9
    Issue number13
    DOIs
    StatePublished - Jul 7 2020

    Keywords

    • anticoagulation
    • oral direct thrombin inhibitor
    • oral factor Xa inhibitors
    • pharmacotherapy

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    Fingerprint Dive into the research topics of 'Direct Oral Anticoagulant Use: A Practical Guide to Common Clinical Challenges'. Together they form a unique fingerprint.

    Cite this