Direct observation of oxygen rebound with an iron-hydroxide complex

Jan Paulo T. Zaragoza, Timothy H. Yosca, Maxime A. Siegler, Pierre Moenne-Loccoz, Michael T. Green, David P. Goldberg

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The rebound mechanism for alkane hydroxylation was invoked over 40 years ago to help explain reactivity patterns in cytochrome P450, and subsequently has been used to provide insight into a range of biological and synthetic systems. Efforts to model the rebound reaction in a synthetic system have been unsuccessful, in part because of the challenge in preparing a suitable metalhydroxide complex at the correct oxidation level. Herein we report the synthesis of such a complex. The reaction of this species with a series of substituted radicals allows for the direct interrogation of the rebound process, providing insight into this uniformly invoked, but previously unobserved process.

Original languageEnglish (US)
Pages (from-to)13640-13643
Number of pages4
JournalJournal of the American Chemical Society
Volume139
Issue number39
DOIs
StatePublished - 2017

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Hydroxylation
Alkanes
Paraffins
Cytochrome P-450 Enzyme System
Iron
Observation
Oxygen
Oxidation
hydroxide ion

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Zaragoza, J. P. T., Yosca, T. H., Siegler, M. A., Moenne-Loccoz, P., Green, M. T., & Goldberg, D. P. (2017). Direct observation of oxygen rebound with an iron-hydroxide complex. Journal of the American Chemical Society, 139(39), 13640-13643. https://doi.org/10.1021/jacs.7b07979

Direct observation of oxygen rebound with an iron-hydroxide complex. / Zaragoza, Jan Paulo T.; Yosca, Timothy H.; Siegler, Maxime A.; Moenne-Loccoz, Pierre; Green, Michael T.; Goldberg, David P.

In: Journal of the American Chemical Society, Vol. 139, No. 39, 2017, p. 13640-13643.

Research output: Contribution to journalArticle

Zaragoza, JPT, Yosca, TH, Siegler, MA, Moenne-Loccoz, P, Green, MT & Goldberg, DP 2017, 'Direct observation of oxygen rebound with an iron-hydroxide complex', Journal of the American Chemical Society, vol. 139, no. 39, pp. 13640-13643. https://doi.org/10.1021/jacs.7b07979
Zaragoza, Jan Paulo T. ; Yosca, Timothy H. ; Siegler, Maxime A. ; Moenne-Loccoz, Pierre ; Green, Michael T. ; Goldberg, David P. / Direct observation of oxygen rebound with an iron-hydroxide complex. In: Journal of the American Chemical Society. 2017 ; Vol. 139, No. 39. pp. 13640-13643.
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