Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue

Danny M. Skyba; Richard J. Price; Andre Z. Linka; Thomas C. Skalak; Sanjiv Kaul

doi:10.1161/01.CIR.98.4.290

Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue

Danny M. Skyba, Richard J. Price, Andre Z. Linka, Thomas C. Skalak, Sanjiv Kaul

Research output: Contribution to journal › Article › peer-review

441 Scopus citations

Abstract

Background--Our aim was to observe ultrasound-induced intravascular microbubble destruction in vivo and to characterize any resultant bioeffects. Methods and Results--Intravital microscopy was used to visualize the spinotrapezius muscle in 15 rats during ultrasound delivery. Microbubble destruction during ultrasound exposure caused rupture of ≤7-μm microvessels (mostly capillaries) and the production of nonviable cells in adjacent tissue. The number of microvessels ruptured and cells damaged correlated linearly (P<0.001) with the amount of ultrasound energy delivered. Conclusions--Microbubbles can be destroyed by ultrasound, resulting in a bioeffect that could be used for local drug delivery, angiogenesis, and vascular remodeling, or for tumor destruction.

Original language	English (US)
Pages (from-to)	290-293
Number of pages	4
Journal	Circulation
Volume	98
Issue number	4
DOIs	https://doi.org/10.1161/01.CIR.98.4.290
State	Published - Jul 28 1998
Externally published	Yes

Keywords

Microspheres
Tissue
Ultrasonics

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1161/01.CIR.98.4.290

Cite this

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abstract = "Background--Our aim was to observe ultrasound-induced intravascular microbubble destruction in vivo and to characterize any resultant bioeffects. Methods and Results--Intravital microscopy was used to visualize the spinotrapezius muscle in 15 rats during ultrasound delivery. Microbubble destruction during ultrasound exposure caused rupture of ≤7-μm microvessels (mostly capillaries) and the production of nonviable cells in adjacent tissue. The number of microvessels ruptured and cells damaged correlated linearly (P<0.001) with the amount of ultrasound energy delivered. Conclusions--Microbubbles can be destroyed by ultrasound, resulting in a bioeffect that could be used for local drug delivery, angiogenesis, and vascular remodeling, or for tumor destruction.",

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AU - Skyba, Danny M.

AU - Price, Richard J.

AU - Linka, Andre Z.

AU - Skalak, Thomas C.

AU - Kaul, Sanjiv

PY - 1998/7/28

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AB - Background--Our aim was to observe ultrasound-induced intravascular microbubble destruction in vivo and to characterize any resultant bioeffects. Methods and Results--Intravital microscopy was used to visualize the spinotrapezius muscle in 15 rats during ultrasound delivery. Microbubble destruction during ultrasound exposure caused rupture of ≤7-μm microvessels (mostly capillaries) and the production of nonviable cells in adjacent tissue. The number of microvessels ruptured and cells damaged correlated linearly (P<0.001) with the amount of ultrasound energy delivered. Conclusions--Microbubbles can be destroyed by ultrasound, resulting in a bioeffect that could be used for local drug delivery, angiogenesis, and vascular remodeling, or for tumor destruction.

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Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue

Abstract

Keywords

ASJC Scopus subject areas

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