Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue

Danny M. Skyba, Richard J. Price, Andre Z. Linka, Thomas C. Skalak, Sanjiv Kaul

Research output: Contribution to journalArticle

397 Citations (Scopus)

Abstract

Background--Our aim was to observe ultrasound-induced intravascular microbubble destruction in vivo and to characterize any resultant bioeffects. Methods and Results--Intravital microscopy was used to visualize the spinotrapezius muscle in 15 rats during ultrasound delivery. Microbubble destruction during ultrasound exposure caused rupture of ≤7-μm microvessels (mostly capillaries) and the production of nonviable cells in adjacent tissue. The number of microvessels ruptured and cells damaged correlated linearly (P

Original languageEnglish (US)
Pages (from-to)290-293
Number of pages4
JournalCirculation
Volume98
Issue number4
StatePublished - Jul 28 1998
Externally publishedYes

Fingerprint

Microbubbles
Microvessels
Rupture
Muscles
Intravital Microscopy

Keywords

  • Microspheres
  • Tissue
  • Ultrasonics

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue. / Skyba, Danny M.; Price, Richard J.; Linka, Andre Z.; Skalak, Thomas C.; Kaul, Sanjiv.

In: Circulation, Vol. 98, No. 4, 28.07.1998, p. 290-293.

Research output: Contribution to journalArticle

Skyba, Danny M. ; Price, Richard J. ; Linka, Andre Z. ; Skalak, Thomas C. ; Kaul, Sanjiv. / Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue. In: Circulation. 1998 ; Vol. 98, No. 4. pp. 290-293.
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