Direct effect of the luteinizing hormone releasing hormone analog D-Trp6-Pro9-Net-LHRH on rat ovarian steroidogenesis

S. Malozowski, F. Cassorla, M. Gelato, M. Nicoletti, R. D'Agata, V. Mericq, Donald (Lynn) Loriaux

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The luteinizing hormone releasing hormone analog D-Trp6-Pro9-Net-LHRH (LHRH(a)) inhibits rat ovarian estradiol secretion. To determine whether LHRH(a) decreases serum estradiol concentrations solely by inhibiting gonadotropin secretion or, in addition, by influencing directly ovarian estradiol biosynthesis, we examined the effects of LHRH(a) on the activities of 5 key ovarian steroidogenic enzymes. Fifty hypophysectomized, gonadotropin-treated rats were given either LHRH(a) (1 μg/day) or saline sc during 7 days. The LHRH(a) treated animals exhibited a significant decrease in serum estradiol when compared with the control group (461 ± 30 vs 31 ± 5 pg/ml, mean ± SE, P

Original languageEnglish (US)
Pages (from-to)321-322
Number of pages2
JournalHormone and Metabolic Research
Volume17
Issue number6
StatePublished - 1985
Externally publishedYes

Fingerprint

Gonadotropin-Releasing Hormone
Rats
Estradiol
Gonadotropins
Biosynthesis
Serum
Animals
Control Groups
Enzymes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Direct effect of the luteinizing hormone releasing hormone analog D-Trp6-Pro9-Net-LHRH on rat ovarian steroidogenesis. / Malozowski, S.; Cassorla, F.; Gelato, M.; Nicoletti, M.; D'Agata, R.; Mericq, V.; Loriaux, Donald (Lynn).

In: Hormone and Metabolic Research, Vol. 17, No. 6, 1985, p. 321-322.

Research output: Contribution to journalArticle

Malozowski, S, Cassorla, F, Gelato, M, Nicoletti, M, D'Agata, R, Mericq, V & Loriaux, DL 1985, 'Direct effect of the luteinizing hormone releasing hormone analog D-Trp6-Pro9-Net-LHRH on rat ovarian steroidogenesis', Hormone and Metabolic Research, vol. 17, no. 6, pp. 321-322.
Malozowski S, Cassorla F, Gelato M, Nicoletti M, D'Agata R, Mericq V et al. Direct effect of the luteinizing hormone releasing hormone analog D-Trp6-Pro9-Net-LHRH on rat ovarian steroidogenesis. Hormone and Metabolic Research. 1985;17(6):321-322.
Malozowski, S. ; Cassorla, F. ; Gelato, M. ; Nicoletti, M. ; D'Agata, R. ; Mericq, V. ; Loriaux, Donald (Lynn). / Direct effect of the luteinizing hormone releasing hormone analog D-Trp6-Pro9-Net-LHRH on rat ovarian steroidogenesis. In: Hormone and Metabolic Research. 1985 ; Vol. 17, No. 6. pp. 321-322.
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