TY - JOUR
T1 - Diplopia and HMG-CoA reductase inhibitors
AU - Fraunfelder, F. W.
AU - Fraunfelder, F. T.
AU - Edwards, Ralph
N1 - Funding Information:
This study was supported, in part, by an unrestricted grant from Research to Prevent Blindness, New York, NY (to Dr. F.T. Fraunfelder).
PY - 1999
Y1 - 1999
N2 - Seventy-one cases of possible diplopia associated with cholesterol- lowering, HMG-CoA reductase inhibitors lovastatin, simvastatin, pravastatin, or fluvastatin are reviewed. Cases were received from spontaneous reporting systems, and while these data are incomplete, two cases recurred on rechallenge and 31 had positive dechallenge tests. This suggests that these agents may cause diplopia in some patients. Diplopia may be a potential marker of these agents' drug-induced, generalized muscle dysfunction.
AB - Seventy-one cases of possible diplopia associated with cholesterol- lowering, HMG-CoA reductase inhibitors lovastatin, simvastatin, pravastatin, or fluvastatin are reviewed. Cases were received from spontaneous reporting systems, and while these data are incomplete, two cases recurred on rechallenge and 31 had positive dechallenge tests. This suggests that these agents may cause diplopia in some patients. Diplopia may be a potential marker of these agents' drug-induced, generalized muscle dysfunction.
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U2 - 10.3109/15569529909065546
DO - 10.3109/15569529909065546
M3 - Article
AN - SCOPUS:0032736732
SN - 0731-3829
VL - 18
SP - 287
EP - 289
JO - Journal of Toxicology - Cutaneous and Ocular Toxicology
JF - Journal of Toxicology - Cutaneous and Ocular Toxicology
IS - 4
ER -