Dimeric inhibin

A direct marker of ovarian aging

Douglas R. Danforth, Laura K. Arbogast, Jamil Mroueh, Moon H. Kim, Elizabeth A. Kennard, David Seifer, Chad I. Friedman

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Objective: To investigate whether luteal secretion of inhibin-a is altered in the perimenopausal transition and to evaluate whether luteal inhibin secretion is correlated with other markers of ovarian reserve such as FSH and inhibin-b. Design: Prospective study. Setting: Reproductive Endocrinology Laboratories at The Ohio State University. Patient(s): Twenty- five women 39-52 years of age with regular menstrual cycles. Intervention(s): Daily urine samples were monitored (LH predictor kit) to identify the day of ovulation. Blood samples obtained on days 6 and 8 after the LH surge and on day 3 of the subsequent follicular phase were assayed for FSH, E2, progesterone, inhibin-a, and inhibin-b. Main Outcome Measure(s): Serum levels of inhibin-a, inhibin-b, FSH, E2, and progesterone. Result(s): Luteal phase inhibin-a and follicular phase inhibin-b were correlated inversely with age in perimenopausal women. In addition, luteal phase inhibin-a and follicular phase inhibin-b levels were correlated inversely with follicular phase FSH levels. Conclusion(s): Both luteal phase inhibin-a and follicular phase inhibin-b levels are correlated inversely with age during the fifth decade of life. These findings suggest that corpus luteum function is altered during the perimenopausal transition. Moreover, these direct measures of ovarian function may be more sensitive indicators of 'ovarian reserve' than indirect indicators such as pituitary FSH secretion.

Original languageEnglish (US)
Pages (from-to)119-123
Number of pages5
JournalFertility and Sterility
Volume70
Issue number1
DOIs
StatePublished - Jul 1998
Externally publishedYes

Fingerprint

Inhibins
Follicular Phase
Luteal Phase
Corpus Luteum
inhibin A
Progesterone
Endocrinology
Menstrual Cycle
Ovulation

Keywords

  • Corpus luteum
  • Follicle
  • FSH
  • Inhibin
  • Ovarian aging
  • Perimenopause

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Danforth, D. R., Arbogast, L. K., Mroueh, J., Kim, M. H., Kennard, E. A., Seifer, D., & Friedman, C. I. (1998). Dimeric inhibin: A direct marker of ovarian aging. Fertility and Sterility, 70(1), 119-123. https://doi.org/10.1016/S0015-0282(98)00127-7

Dimeric inhibin : A direct marker of ovarian aging. / Danforth, Douglas R.; Arbogast, Laura K.; Mroueh, Jamil; Kim, Moon H.; Kennard, Elizabeth A.; Seifer, David; Friedman, Chad I.

In: Fertility and Sterility, Vol. 70, No. 1, 07.1998, p. 119-123.

Research output: Contribution to journalArticle

Danforth, DR, Arbogast, LK, Mroueh, J, Kim, MH, Kennard, EA, Seifer, D & Friedman, CI 1998, 'Dimeric inhibin: A direct marker of ovarian aging', Fertility and Sterility, vol. 70, no. 1, pp. 119-123. https://doi.org/10.1016/S0015-0282(98)00127-7
Danforth DR, Arbogast LK, Mroueh J, Kim MH, Kennard EA, Seifer D et al. Dimeric inhibin: A direct marker of ovarian aging. Fertility and Sterility. 1998 Jul;70(1):119-123. https://doi.org/10.1016/S0015-0282(98)00127-7
Danforth, Douglas R. ; Arbogast, Laura K. ; Mroueh, Jamil ; Kim, Moon H. ; Kennard, Elizabeth A. ; Seifer, David ; Friedman, Chad I. / Dimeric inhibin : A direct marker of ovarian aging. In: Fertility and Sterility. 1998 ; Vol. 70, No. 1. pp. 119-123.
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abstract = "Objective: To investigate whether luteal secretion of inhibin-a is altered in the perimenopausal transition and to evaluate whether luteal inhibin secretion is correlated with other markers of ovarian reserve such as FSH and inhibin-b. Design: Prospective study. Setting: Reproductive Endocrinology Laboratories at The Ohio State University. Patient(s): Twenty- five women 39-52 years of age with regular menstrual cycles. Intervention(s): Daily urine samples were monitored (LH predictor kit) to identify the day of ovulation. Blood samples obtained on days 6 and 8 after the LH surge and on day 3 of the subsequent follicular phase were assayed for FSH, E2, progesterone, inhibin-a, and inhibin-b. Main Outcome Measure(s): Serum levels of inhibin-a, inhibin-b, FSH, E2, and progesterone. Result(s): Luteal phase inhibin-a and follicular phase inhibin-b were correlated inversely with age in perimenopausal women. In addition, luteal phase inhibin-a and follicular phase inhibin-b levels were correlated inversely with follicular phase FSH levels. Conclusion(s): Both luteal phase inhibin-a and follicular phase inhibin-b levels are correlated inversely with age during the fifth decade of life. These findings suggest that corpus luteum function is altered during the perimenopausal transition. Moreover, these direct measures of ovarian function may be more sensitive indicators of 'ovarian reserve' than indirect indicators such as pituitary FSH secretion.",
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