Digital tomosynthesis for respiratory gated liver treatment: Clinical feasibility for daily image guidance

Q. Jackie Wu, Jeffrey Meyer, Jessica Fuller, Devon Godfrey, Zhiheng Wang, Junan Zhang, Fang Fang Yin

Research output: Contribution to journalArticle

8 Scopus citations


Purpose: Breath-hold (BH) treatment minimizes internal target volumes (ITV) when treating sites prone to motion. Digital tomosynthesis (DTS) imaging has advantages over cone-beam CT (CBCT) for BH imaging: BH-DTS scan can be completed during a single breath-hold, whereas BH-CBCT is usually acquired by parsing the gantry rotation into multiple BH segments. This study evaluates the localization accuracy of DTS for BH treatment of liver tumors. Methods: Both planning CT and on-board DTS/CBCT images were acquired under BH, using the planning CT BH window as reference. Onboard imaging data sets included two independent DTS orientations (coronal and sagittal), and CBCT images. Soft tissue target positioning was measured by each imaging modality and translated into couch shifts. Performance of the two DTS orientations was evaluated by comparing target positioning with the CBCT benchmark, determined by two observers. Results: Image data sets were collected from thirty-eight treatment fractions (14 patients). Mean differences between the two DTS methods and the CBCT method were

Original languageEnglish (US)
Pages (from-to)289-296
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number1
Publication statusPublished - Jan 1 2011
Externally publishedYes



  • Breath hold
  • Digital tomosynthesis
  • Image guidance
  • liver
  • Respiratory motion

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

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