Diffusion tensor imaging suggests extrapontine extension of pediatric diffuse intrinsic pontine gliomas

Matthias W. Wagner, W. Robert Bell, Jason Kern, Thangamadhan Bosemani, Joyce Mhlanga, Kathryn A. Carson, Kenneth J. Cohen, Eric H. Raabe, Fausto Rodriguez, Thierry A G M Huisman, Andrea Poretti

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose To apply DTI to detect early extrapontine extension of pediatric diffuse intrinsic pontine glioma along the corticospinal tracts. Methods In children with diffuse intrinsic pontine glioma, low-grade brainstem glioma, and age-matched controls, DTI metrics were measured in the posterior limb of the internal capsule and posterior centrum semiovale. Histological examination was available in one patient. Results 6 diffuse intrinsic pontine glioma, 8 low-grade brainstem glioma, and two groups of 25 controls were included. In diffuse intrinsic pontine glioma compared to controls, fractional anisotropy was lower in the bilateral posterior limb of the internal capsule, axial diffusivity was lower in the bilateral posterior centrum semiovale and posterior limb of the internal capsule, while radial diffusivity was higher in the bilateral posterior limb of the internal capsule. No significant differences were found between low-grade brainstem glioma and controls. In diffuse intrinsic pontine glioma compared to low-grade brainstem glioma, axial diffusivity was lower in the bilateral posterior limb of the internal capsule. Histological examination in one child showed tumor cells in the posterior limb of the internal capsule. Conclusion Reduction in fractional anisotropy and axial diffusivity and increase in radial diffusivity in diffuse intrinsic pontine glioma may reflect tumor extension along the corticospinal tracts as shown by histology. DTI may detect early extrapontine tumor extension in diffuse intrinsic pontine glioma before it becomes apparent on conventional MRI sequences.

Original languageEnglish (US)
Pages (from-to)700-706
Number of pages7
JournalEuropean Journal of Radiology
Volume85
Issue number4
DOIs
StatePublished - Apr 1 2016
Externally publishedYes

Fingerprint

Diffusion Tensor Imaging
Glioma
Internal Capsule
Pediatrics
Extremities
Brain Stem
Pyramidal Tracts
Anisotropy
Neoplasms
Histology

Keywords

  • Children
  • Corticospinal tract
  • Diffuse intrinsic pontine glioma
  • Diffusion tensor imaging
  • Extrapontine extension
  • Neuroimaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Wagner, M. W., Bell, W. R., Kern, J., Bosemani, T., Mhlanga, J., Carson, K. A., ... Poretti, A. (2016). Diffusion tensor imaging suggests extrapontine extension of pediatric diffuse intrinsic pontine gliomas. European Journal of Radiology, 85(4), 700-706. https://doi.org/10.1016/j.ejrad.2016.02.004

Diffusion tensor imaging suggests extrapontine extension of pediatric diffuse intrinsic pontine gliomas. / Wagner, Matthias W.; Bell, W. Robert; Kern, Jason; Bosemani, Thangamadhan; Mhlanga, Joyce; Carson, Kathryn A.; Cohen, Kenneth J.; Raabe, Eric H.; Rodriguez, Fausto; Huisman, Thierry A G M; Poretti, Andrea.

In: European Journal of Radiology, Vol. 85, No. 4, 01.04.2016, p. 700-706.

Research output: Contribution to journalArticle

Wagner, MW, Bell, WR, Kern, J, Bosemani, T, Mhlanga, J, Carson, KA, Cohen, KJ, Raabe, EH, Rodriguez, F, Huisman, TAGM & Poretti, A 2016, 'Diffusion tensor imaging suggests extrapontine extension of pediatric diffuse intrinsic pontine gliomas', European Journal of Radiology, vol. 85, no. 4, pp. 700-706. https://doi.org/10.1016/j.ejrad.2016.02.004
Wagner, Matthias W. ; Bell, W. Robert ; Kern, Jason ; Bosemani, Thangamadhan ; Mhlanga, Joyce ; Carson, Kathryn A. ; Cohen, Kenneth J. ; Raabe, Eric H. ; Rodriguez, Fausto ; Huisman, Thierry A G M ; Poretti, Andrea. / Diffusion tensor imaging suggests extrapontine extension of pediatric diffuse intrinsic pontine gliomas. In: European Journal of Radiology. 2016 ; Vol. 85, No. 4. pp. 700-706.
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abstract = "Purpose To apply DTI to detect early extrapontine extension of pediatric diffuse intrinsic pontine glioma along the corticospinal tracts. Methods In children with diffuse intrinsic pontine glioma, low-grade brainstem glioma, and age-matched controls, DTI metrics were measured in the posterior limb of the internal capsule and posterior centrum semiovale. Histological examination was available in one patient. Results 6 diffuse intrinsic pontine glioma, 8 low-grade brainstem glioma, and two groups of 25 controls were included. In diffuse intrinsic pontine glioma compared to controls, fractional anisotropy was lower in the bilateral posterior limb of the internal capsule, axial diffusivity was lower in the bilateral posterior centrum semiovale and posterior limb of the internal capsule, while radial diffusivity was higher in the bilateral posterior limb of the internal capsule. No significant differences were found between low-grade brainstem glioma and controls. In diffuse intrinsic pontine glioma compared to low-grade brainstem glioma, axial diffusivity was lower in the bilateral posterior limb of the internal capsule. Histological examination in one child showed tumor cells in the posterior limb of the internal capsule. Conclusion Reduction in fractional anisotropy and axial diffusivity and increase in radial diffusivity in diffuse intrinsic pontine glioma may reflect tumor extension along the corticospinal tracts as shown by histology. DTI may detect early extrapontine tumor extension in diffuse intrinsic pontine glioma before it becomes apparent on conventional MRI sequences.",
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AU - Mhlanga, Joyce

AU - Carson, Kathryn A.

AU - Cohen, Kenneth J.

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