Diffuse microglial proliferation after global ischemia in a patient with aplastic bone marrow

E. A. Neuwelt, J. H. Garcia, H. Mena

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Abundant proliferation of cells having the histologic and tinctorial features of microglia, were seen in the brain of 34-year-old man who suffered cardiac arrest 10 days before death and whose bone marrow was nearly totally depleted of white-blood-cell precursors. It is suggested, that in adult human brains there are native microglial precursors which can take on a phagocytic function. Therefore, brain macrophages do not have to originate from circulating monocytes, as suggested by some animal studies.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalActa Neuropathologica
Volume43
Issue number3
DOIs
StatePublished - Jan 1 1978

Keywords

  • Human brain inflammation
  • Ischemia
  • Microglia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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