Diffuse light tomography to detect blood vessels using Tikhonov regularization

Huseyin Ozgur Kazanci, Steven L. Jacques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

Detection of blood vessels within light-scattering tissues involves detection of subtle shadows as blood absorbs light. These shadows are diffuse but measurable by a set of source-detector pairs in a spatial array of sources and detectors on the tissue surface. The measured shadows can reconstruct the internal position(s) of blood vessels. The tomographic method involves a set of Ns sources and Nd detectors such that Nsd = Ns x Nd source-detector pairs produce Nsd measurements, each interrogating the tissue with a unique perspective, i.e., a unique region of sensitivity to voxels within the tissue. This tutorial report describes the reconstruction of the image of a blood vessel within a soft tissue based on such source-detector measurements, by solving a matrix equation using Tikhonov regularization. This is not a novel contribution, but rather a simple introduction to a well-known method, demonstrating its use in mapping blood perfusion.

Original languageEnglish (US)
Title of host publicationSaratov Fall Meeting 2015 - Third International Symposium on Optics and Biophotonics; and Seventh Finnish-Russian Photonics and Laser Symposium (PALS)
EditorsKirill V. Larin, Alexander B. Pravdin, Valery V. Tuchin, Igor V. Meglinski, Elina A. Genina, Vladimir L. Derbov, Dmitry E. Postnov
PublisherSPIE
ISBN (Electronic)9781510602267
DOIs
StatePublished - 2016
Event3rd International Symposium on Optics and Biophotonics, SFM 2015 and 7th Finnish-Russian Photonics and Laser Symposium, PALS 2015 - Saratov, Russian Federation
Duration: Sep 22 2015Sep 25 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9917
ISSN (Print)1605-7422

Other

Other3rd International Symposium on Optics and Biophotonics, SFM 2015 and 7th Finnish-Russian Photonics and Laser Symposium, PALS 2015
Country/TerritoryRussian Federation
CitySaratov
Period9/22/159/25/15

Keywords

  • Biomedical optic
  • Diffuse light tomography
  • Diffuse optic imaging
  • Diffuse optical tomography
  • Inverse problem solution
  • Laser imaging
  • Monte carlo simulation
  • Tikhonov regularization

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Biomaterials

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