Diffuse light tomography to detect blood vessels using Tikhonov regularization

Huseyin Ozgur Kazanci, Steven Jacques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

Detection of blood vessels within light-scattering tissues involves detection of subtle shadows as blood absorbs light. These shadows are diffuse but measurable by a set of source-detector pairs in a spatial array of sources and detectors on the tissue surface. The measured shadows can reconstruct the internal position(s) of blood vessels. The tomographic method involves a set of Ns sources and Nd detectors such that Nsd = Ns x Nd source-detector pairs produce Nsd measurements, each interrogating the tissue with a unique perspective, i.e., a unique region of sensitivity to voxels within the tissue. This tutorial report describes the reconstruction of the image of a blood vessel within a soft tissue based on such source-detector measurements, by solving a matrix equation using Tikhonov regularization. This is not a novel contribution, but rather a simple introduction to a well-known method, demonstrating its use in mapping blood perfusion.

Original languageEnglish (US)
Title of host publicationSaratov Fall Meeting 2015 - Third International Symposium on Optics and Biophotonics; and Seventh Finnish-Russian Photonics and Laser Symposium (PALS)
PublisherSPIE
Volume9917
ISBN (Electronic)9781510602267
DOIs
StatePublished - 2016
Event3rd International Symposium on Optics and Biophotonics, SFM 2015 and 7th Finnish-Russian Photonics and Laser Symposium, PALS 2015 - Saratov, Russian Federation
Duration: Sep 22 2015Sep 25 2015

Other

Other3rd International Symposium on Optics and Biophotonics, SFM 2015 and 7th Finnish-Russian Photonics and Laser Symposium, PALS 2015
CountryRussian Federation
CitySaratov
Period9/22/159/25/15

Keywords

  • Biomedical optic
  • Diffuse light tomography
  • Diffuse optic imaging
  • Diffuse optical tomography
  • Inverse problem solution
  • Laser imaging
  • Monte carlo simulation
  • Tikhonov regularization

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Kazanci, H. O., & Jacques, S. (2016). Diffuse light tomography to detect blood vessels using Tikhonov regularization. In Saratov Fall Meeting 2015 - Third International Symposium on Optics and Biophotonics; and Seventh Finnish-Russian Photonics and Laser Symposium (PALS) (Vol. 9917). [99170T] SPIE. https://doi.org/10.1117/12.2230074