Differentiating among stages of cognitive impairment in aging: Version 3 of the Uniform Data Set (UDS) neuropsychological test battery and MoCA index scores

Hiroko H. Dodge, Felicia C. Goldstein, Nicole I. Wakim, Tamar Gefen, Merilee Teylan, Kwun C.G. Chan, Walter A. Kukull, Lisa L. Barnes, Bruno Giordani, Timothy M. Hughes, Joel H. Kramer, David A. Loewenstein, Daniel C. Marson, Dan M. Mungas, Nora Mattek, Bonnie C. Sachs, David P. Salmon, Monica Willis-Parker, Kathleen A. Welsh-Bohmer, Katherine V. WildJohn C. Morris, Sandra Weintraub

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Introduction: Federally funded Alzheimer’s Disease Centers in the United States have been using a standardized neuropsychological test battery as part of the National Alzheimer’s Coordinating Center Uniform Data Set (UDS) since 2005. Version 3 (V3) of the UDS replaced the previous version (V2) in 2015.We compared V2 and V3 neuropsychological tests with respect to their ability to distinguish among the Clinical Dementia Rating (CDR) global scores of 0, 0.5, and 1. Methods: First, we matched participants receiving V2 tests (V2 cohort) and V3 tests (V3 cohort) in their cognitive functions using tests common to both versions. Then, we compared receiver-operating characteristic (ROC) area under the curve in differentiating CDRs for the remaining tests. Results: Some V3 tests performed better thanV2 tests in differentiating betweenCDR 0.5 and 0, but the improvement was limited to Caucasian participants. Discussion: Further efforts to improve the ability for early identification of cognitive decline among diverse racial groups are required.

Original languageEnglish (US)
Article numbere12103
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Volume6
Issue number1
DOIs
StatePublished - 2020

Keywords

  • differentiating CDR
  • National Alzheimer’s Coordinating Center Uniform Data Set (NACC UDS)
  • optimal cut-point
  • racial differences
  • receiver-operating characteristic area under the curve (ROC-AUC)
  • validity

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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