Differential stimulation of hepatic and brain metallothioneins by ethanol

M. Ebadi, Ronald Pfeiffer, A. Huff

Research output: Contribution to journalArticle

16 Scopus citations


Administration of ethanol induces the synthesis of hepatic metallothionein and metallothionein mRNA in the liver but not in the brain. Furthermore, ethyl alcohol, methyl alcohol and isopropyl alcohol enhance the synthesis of metallothionein in Chang cells but not in neuroblastoma IMR-32 cells in culture. The results of this study are interpreted to suggest that the mechanisms of synthesis of metallothionein and the utilization of essential metal nutrients in the brain and peripheral tissues are not identical.

Original languageEnglish (US)
Pages (from-to)555-562
Number of pages8
JournalNeurochemistry International
Issue number4
Publication statusPublished - 1992
Externally publishedYes


ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

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