Differential stimulation of hepatic and brain metallothioneins by ethanol

M. Ebadi; R. F. Pfeiffer; A. Huff

doi:10.1016/0197-0186(92)90088-9

Differential stimulation of hepatic and brain metallothioneins by ethanol

M. Ebadi, R. F. Pfeiffer, A. Huff

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Administration of ethanol induces the synthesis of hepatic metallothionein and metallothionein mRNA in the liver but not in the brain. Furthermore, ethyl alcohol, methyl alcohol and isopropyl alcohol enhance the synthesis of metallothionein in Chang cells but not in neuroblastoma IMR-32 cells in culture. The results of this study are interpreted to suggest that the mechanisms of synthesis of metallothionein and the utilization of essential metal nutrients in the brain and peripheral tissues are not identical.

Original language	English (US)
Pages (from-to)	555-562
Number of pages	8
Journal	Neurochemistry International
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/0197-0186(92)90088-9
State	Published - Dec 1992
Externally published	Yes

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Cell Biology

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title = "Differential stimulation of hepatic and brain metallothioneins by ethanol",

abstract = "Administration of ethanol induces the synthesis of hepatic metallothionein and metallothionein mRNA in the liver but not in the brain. Furthermore, ethyl alcohol, methyl alcohol and isopropyl alcohol enhance the synthesis of metallothionein in Chang cells but not in neuroblastoma IMR-32 cells in culture. The results of this study are interpreted to suggest that the mechanisms of synthesis of metallothionein and the utilization of essential metal nutrients in the brain and peripheral tissues are not identical.",

author = "M. Ebadi and Pfeiffer, {R. F.} and A. Huff",

year = "1992",

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T1 - Differential stimulation of hepatic and brain metallothioneins by ethanol

AU - Ebadi, M.

AU - Pfeiffer, R. F.

AU - Huff, A.

PY - 1992/12

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N2 - Administration of ethanol induces the synthesis of hepatic metallothionein and metallothionein mRNA in the liver but not in the brain. Furthermore, ethyl alcohol, methyl alcohol and isopropyl alcohol enhance the synthesis of metallothionein in Chang cells but not in neuroblastoma IMR-32 cells in culture. The results of this study are interpreted to suggest that the mechanisms of synthesis of metallothionein and the utilization of essential metal nutrients in the brain and peripheral tissues are not identical.

AB - Administration of ethanol induces the synthesis of hepatic metallothionein and metallothionein mRNA in the liver but not in the brain. Furthermore, ethyl alcohol, methyl alcohol and isopropyl alcohol enhance the synthesis of metallothionein in Chang cells but not in neuroblastoma IMR-32 cells in culture. The results of this study are interpreted to suggest that the mechanisms of synthesis of metallothionein and the utilization of essential metal nutrients in the brain and peripheral tissues are not identical.

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Differential stimulation of hepatic and brain metallothioneins by ethanol

Abstract

ASJC Scopus subject areas

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