Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines

    Research output: Contribution to journalArticle

    38 Citations (Scopus)

    Abstract

    Robust CD8+ T-cell activation is vital for the recovery from many viral infections and is orchestrated via the integration of signals delivered through surface molecules, including the T-cell antigen receptors (TcRs) and cytokine receptors. Little is known about how virus-specific T cells interpret sequential or combined stimulation through these receptors, which must undoubtedly occur in vivo during antiviral immune responses. When measured in real time, peptide antigen and the cytokines, interleukin 12 (IL-12) and IL-18, independently regulate the on/off kinetics of protective (Interferon γ, tumor necrosis factor α) and immunomodulatory (IL-2, CD40L) cytokine production by activated T cells and memory T cells. The remarkable differences in effector functions elicited by innate or adaptive signals (IL-12/ IL-18 or peptide, respectively) illustrate the complex and stringent regulation of cytokine expression by CD8+ T cells. Together, these results indicate how antiviral T cells incorporate multiple signals from their local microenvironment and tailor their cytokine responses accordingly.

    Original languageEnglish (US)
    Pages (from-to)1179-1186
    Number of pages8
    JournalBlood
    Volume105
    Issue number3
    DOIs
    StatePublished - Feb 1 2005

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    T-cells
    Viruses
    Chemical activation
    Cytokines
    T-Lymphocytes
    Peptides
    Interleukin-18
    Interleukin-12
    Antiviral Agents
    CD40 Ligand
    Cytokine Receptors
    Virus Diseases
    T-Cell Antigen Receptor
    Interferons
    Interleukin-2
    Tumor Necrosis Factor-alpha
    Antigens
    Data storage equipment
    Recovery
    Molecules

    ASJC Scopus subject areas

    • Hematology

    Cite this

    Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines. / Beadling, Carol; Slifka, Mark.

    In: Blood, Vol. 105, No. 3, 01.02.2005, p. 1179-1186.

    Research output: Contribution to journalArticle

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