Differential neurosensitivity to three alcohols and phenobarbital in C57BL/6J and DBA/2J mice

J. K. Belknap, C. K. Deutsch

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Neurosensitivity to ethanol, t-butanol, 1,2-propranediol, and phenobarbital was assessed in C57BL/6J and DBA/2J mice by means of the grid test, a measure of drug-induced ambulatory ataxia. In addition, blood and brain alcohol concentrations at the time of regaining the righting reflex were determined for ethanol and t-butanol. C57BL/6J mice were consistently more neurosensitive than DBA/2J mice to all four drugs on these two tests, but no strain difference was seen with regard to alcohol-induced hypothermia. These findings, and others reported in the literature, indicate that the strain differences in neurosensitivity are very much task dependent in that some measures yield no differences while other measures produce large differences between these two strains. Thus, one strain is not uniformly more sensitive to ethanol than the other across all measures.

Original languageEnglish (US)
Pages (from-to)309-317
Number of pages9
JournalBehavior genetics
Volume12
Issue number3
DOIs
StatePublished - May 1 1982

Keywords

  • 1,2-propanediol
  • C57BL/6
  • DBA/2
  • blood alcohol concentrations
  • ethanol
  • inbred mice
  • phenobarbital
  • t-butanol

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Differential neurosensitivity to three alcohols and phenobarbital in C57BL/6J and DBA/2J mice'. Together they form a unique fingerprint.

  • Cite this