Differential macrophage programming in the tumor microenvironment

Brian Ruffell, Nesrine I. Affara, Lisa M. Coussens

Research output: Contribution to journalReview articlepeer-review

467 Scopus citations

Abstract

Of the multiple unique stromal cell types common to solid tumors, tumor-associated macrophages (TAMs) are significant for fostering tumor progression. The protumor properties of TAMs derive from regulation of angiogenic programming, production of soluble mediators that support proliferation, survival and invasion of malignant cells, and direct and indirect suppression of cytotoxic T cell activity. These varied activities are dependent on the polarization state of TAMs that is regulated in part by local concentrations of cytokines and chemokines, as well as varied interactions of TAMs with normal and degraded components of the extracellular matrix. Targeting molecular pathways regulating TAM polarization holds great promise for anticancer therapy.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalTrends in Immunology
Volume33
Issue number3
DOIs
StatePublished - Mar 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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