Differential macrophage programming in the tumor microenvironment

Brian Ruffell, Nesrine I. Affara, Lisa Coussens

Research output: Contribution to journalArticle

414 Citations (Scopus)

Abstract

Of the multiple unique stromal cell types common to solid tumors, tumor-associated macrophages (TAMs) are significant for fostering tumor progression. The protumor properties of TAMs derive from regulation of angiogenic programming, production of soluble mediators that support proliferation, survival and invasion of malignant cells, and direct and indirect suppression of cytotoxic T cell activity. These varied activities are dependent on the polarization state of TAMs that is regulated in part by local concentrations of cytokines and chemokines, as well as varied interactions of TAMs with normal and degraded components of the extracellular matrix. Targeting molecular pathways regulating TAM polarization holds great promise for anticancer therapy.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalTrends in Immunology
Volume33
Issue number3
DOIs
StatePublished - Mar 2012
Externally publishedYes

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Tumor Microenvironment
Macrophages
Neoplasms
Foster Home Care
Stromal Cells
Chemokines
Extracellular Matrix
Cytokines
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Differential macrophage programming in the tumor microenvironment. / Ruffell, Brian; Affara, Nesrine I.; Coussens, Lisa.

In: Trends in Immunology, Vol. 33, No. 3, 03.2012, p. 119-126.

Research output: Contribution to journalArticle

Ruffell, Brian ; Affara, Nesrine I. ; Coussens, Lisa. / Differential macrophage programming in the tumor microenvironment. In: Trends in Immunology. 2012 ; Vol. 33, No. 3. pp. 119-126.
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