TY - JOUR
T1 - Differential localization of GABA(B) receptors in the mouse retina
AU - Zhang, Congxiao
AU - Bettler, Bernhard
AU - Duvoisin, Robert M.
PY - 1998/10/26
Y1 - 1998/10/26
N2 - The mRNA distribution of the two cloned GABA(B) receptor variants, GABA(B)R1a and -R1b, was analysed in the retina by non-radioactive in situ hybridization. GABA(B)R1a transcripts were found in the inner nuclear and ganglion cell layers, probably in horizontal, amacrine and ganglion cells, whereas GABA(B)R1b transcripts were detected in the ganglion cell layer only. Together with a recent immunohistochemical localization of GABA(B)R1 in the retina, this indicates a differential targeting of the receptor variants to pre- and postsynaptic sites with GABA(B)R1a and -R1b localized to axonal and dendritic compartments, respectively. In this way, inhibition of neurotransmitter release and slow postsynaptic inhibition could be provided by receptor variants derived from the same gene.
AB - The mRNA distribution of the two cloned GABA(B) receptor variants, GABA(B)R1a and -R1b, was analysed in the retina by non-radioactive in situ hybridization. GABA(B)R1a transcripts were found in the inner nuclear and ganglion cell layers, probably in horizontal, amacrine and ganglion cells, whereas GABA(B)R1b transcripts were detected in the ganglion cell layer only. Together with a recent immunohistochemical localization of GABA(B)R1 in the retina, this indicates a differential targeting of the receptor variants to pre- and postsynaptic sites with GABA(B)R1a and -R1b localized to axonal and dendritic compartments, respectively. In this way, inhibition of neurotransmitter release and slow postsynaptic inhibition could be provided by receptor variants derived from the same gene.
KW - GABA(B)R1
KW - In situ hybridization
KW - Receptor targeting
KW - γ-Amino butyric acid
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U2 - 10.1097/00001756-199810260-00029
DO - 10.1097/00001756-199810260-00029
M3 - Article
C2 - 9855305
AN - SCOPUS:0032569594
VL - 9
SP - 3493
EP - 3497
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 15
ER -