Abstract
The mRNA distribution of the two cloned GABA(B) receptor variants, GABA(B)R1a and -R1b, was analysed in the retina by non-radioactive in situ hybridization. GABA(B)R1a transcripts were found in the inner nuclear and ganglion cell layers, probably in horizontal, amacrine and ganglion cells, whereas GABA(B)R1b transcripts were detected in the ganglion cell layer only. Together with a recent immunohistochemical localization of GABA(B)R1 in the retina, this indicates a differential targeting of the receptor variants to pre- and postsynaptic sites with GABA(B)R1a and -R1b localized to axonal and dendritic compartments, respectively. In this way, inhibition of neurotransmitter release and slow postsynaptic inhibition could be provided by receptor variants derived from the same gene.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3493-3497 |
| Number of pages | 5 |
| Journal | NeuroReport |
| Volume | 9 |
| Issue number | 15 |
| State | Published - Oct 26 1998 |
| Externally published | Yes |
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Keywords
- γ-Amino butyric acid
- GABA(B)R1
- In situ hybridization
- Receptor targeting
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Differential localization of GABA(B) receptors in the mouse retina. / Zhang, Congxiao; Bettler, Bernhard; Duvoisin, Robert.
In: NeuroReport, Vol. 9, No. 15, 26.10.1998, p. 3493-3497.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential localization of GABA(B) receptors in the mouse retina
AU - Zhang, Congxiao
AU - Bettler, Bernhard
AU - Duvoisin, Robert
PY - 1998/10/26
Y1 - 1998/10/26
N2 - The mRNA distribution of the two cloned GABA(B) receptor variants, GABA(B)R1a and -R1b, was analysed in the retina by non-radioactive in situ hybridization. GABA(B)R1a transcripts were found in the inner nuclear and ganglion cell layers, probably in horizontal, amacrine and ganglion cells, whereas GABA(B)R1b transcripts were detected in the ganglion cell layer only. Together with a recent immunohistochemical localization of GABA(B)R1 in the retina, this indicates a differential targeting of the receptor variants to pre- and postsynaptic sites with GABA(B)R1a and -R1b localized to axonal and dendritic compartments, respectively. In this way, inhibition of neurotransmitter release and slow postsynaptic inhibition could be provided by receptor variants derived from the same gene.
AB - The mRNA distribution of the two cloned GABA(B) receptor variants, GABA(B)R1a and -R1b, was analysed in the retina by non-radioactive in situ hybridization. GABA(B)R1a transcripts were found in the inner nuclear and ganglion cell layers, probably in horizontal, amacrine and ganglion cells, whereas GABA(B)R1b transcripts were detected in the ganglion cell layer only. Together with a recent immunohistochemical localization of GABA(B)R1 in the retina, this indicates a differential targeting of the receptor variants to pre- and postsynaptic sites with GABA(B)R1a and -R1b localized to axonal and dendritic compartments, respectively. In this way, inhibition of neurotransmitter release and slow postsynaptic inhibition could be provided by receptor variants derived from the same gene.
KW - γ-Amino butyric acid
KW - GABA(B)R1
KW - In situ hybridization
KW - Receptor targeting
UR - http://www.scopus.com/inward/record.url?scp=0032569594&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032569594&partnerID=8YFLogxK
M3 - Article
VL - 9
SP - 3493
EP - 3497
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 15
ER -