Differential localization of GABA(B) receptors in the mouse retina

Congxiao Zhang, Bernhard Bettler, Robert M. Duvoisin

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The mRNA distribution of the two cloned GABA(B) receptor variants, GABA(B)R1a and -R1b, was analysed in the retina by non-radioactive in situ hybridization. GABA(B)R1a transcripts were found in the inner nuclear and ganglion cell layers, probably in horizontal, amacrine and ganglion cells, whereas GABA(B)R1b transcripts were detected in the ganglion cell layer only. Together with a recent immunohistochemical localization of GABA(B)R1 in the retina, this indicates a differential targeting of the receptor variants to pre- and postsynaptic sites with GABA(B)R1a and -R1b localized to axonal and dendritic compartments, respectively. In this way, inhibition of neurotransmitter release and slow postsynaptic inhibition could be provided by receptor variants derived from the same gene.

Original languageEnglish (US)
Pages (from-to)3493-3497
Number of pages5
JournalNeuroReport
Volume9
Issue number15
DOIs
StatePublished - Oct 26 1998

Keywords

  • GABA(B)R1
  • In situ hybridization
  • Receptor targeting
  • γ-Amino butyric acid

ASJC Scopus subject areas

  • Neuroscience(all)

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