Differential jejunal and colonic adaptation due to resection and IGF-I in parenterally fed rats

Melanie Gillingham, Elizabeth M. Dahly, Hannah V. Carey, Melanee D. Clark, Karen R. Kritsch, Denise M. Ney

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Patients with severe short-bowel syndrome (SBS) often require long-term total parenteral nutrition (TPN) to maintain their nutritional status because of limited intestinal adaptation. Growth factors, including insulin-like growth factor I (IGF-I), are under investigation to promote intestinal adaptation and tolerance to oral feeding. We investigated structural and functional adaptation of the jejunum and colon in four groups of rats maintained with TPN for 7 days after a 60% jejunoileal resection and cecectomy or sham surgery and treatment with IGF-I or vehicle. Resection alone did not stimulate jejunal growth. IGF-I significantly increased jejunal mucosal mass, enterocyte proliferation, and migration rates. IGF-I decreased jejunal sucrase specific activity and reduced active ion transport and ionic permeability; resection alone had no effect. In contrast, resection significantly increased colonic mass and crypt depth but had no effect on active ion transport or ionic permeability. IGF-I had minimal effects on colonic structure. IGF-I but not resection stimulates jejunal adaptation, whereas resection but not IGF-I stimulates colonic growth in rats subjected to a model for human SBS. IGF-I treatment may improve intestinal adaptation in humans with SBS.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume278
Issue number5 41-5
StatePublished - May 2000
Externally publishedYes

Fingerprint

Insulin-Like Growth Factor I
Short Bowel Syndrome
Total Parenteral Nutrition
Ion Transport
Permeability
Sucrase
Enterocytes
Jejunum
Growth
Nutritional Status
Intercellular Signaling Peptides and Proteins
Colon
Placebos

Keywords

  • 60% jejunoileal resection
  • Cecectomy
  • Gut adaptation
  • Ion transport
  • Short-bowel syndrome

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology
  • Physiology (medical)

Cite this

Differential jejunal and colonic adaptation due to resection and IGF-I in parenterally fed rats. / Gillingham, Melanie; Dahly, Elizabeth M.; Carey, Hannah V.; Clark, Melanee D.; Kritsch, Karen R.; Ney, Denise M.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 278, No. 5 41-5, 05.2000.

Research output: Contribution to journalArticle

Gillingham, Melanie ; Dahly, Elizabeth M. ; Carey, Hannah V. ; Clark, Melanee D. ; Kritsch, Karen R. ; Ney, Denise M. / Differential jejunal and colonic adaptation due to resection and IGF-I in parenterally fed rats. In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 2000 ; Vol. 278, No. 5 41-5.
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