Differential induction of H-2K versus H-2D class I major histocompatibility antigens by recombinant γ interferon. Lack of K(k) augmentation in a leukemia virus-induced tumor is due to a cis-dominant effect

W. R. Green, R. F. Rich, Carol Beadling

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10 Citations (Scopus)

Abstract

T-T tumor hybrids were constructed between the AKR SL3 thymoma and an H-2-distinguishable thymoma cell line. Hybrids were stimulated with IFN-γ to determine whether the differential augmentation of H-2D vs. H-2K class I antigen expression by AKR SL3 in response to IFN-γ was due to effects cis or trans to the noninducible K(k) gene. For each of a large number of hybrids tested, the expression of H-2D(b), K(b), and D(k), but not K(k), was substantially enhanced by murine rIFN-γ. These results suggested that the lack of induction of the K(k) gene was due to an alteration cis to K(k) rather than to the presence or absence of K region-specific, trans-acting negative or positive factors, respectively.

Original languageEnglish (US)
Pages (from-to)1616-1624
Number of pages9
JournalJournal of Experimental Medicine
Volume167
Issue number5
StatePublished - 1988
Externally publishedYes

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Oncogenic Viruses
Histocompatibility Antigens Class I
Interferons
Leukemia
Thymoma
Genes
Cell Line
Neoplasms

ASJC Scopus subject areas

  • Immunology

Cite this

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abstract = "T-T tumor hybrids were constructed between the AKR SL3 thymoma and an H-2-distinguishable thymoma cell line. Hybrids were stimulated with IFN-γ to determine whether the differential augmentation of H-2D vs. H-2K class I antigen expression by AKR SL3 in response to IFN-γ was due to effects cis or trans to the noninducible K(k) gene. For each of a large number of hybrids tested, the expression of H-2D(b), K(b), and D(k), but not K(k), was substantially enhanced by murine rIFN-γ. These results suggested that the lack of induction of the K(k) gene was due to an alteration cis to K(k) rather than to the presence or absence of K region-specific, trans-acting negative or positive factors, respectively.",
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AU - Green, W. R.

AU - Rich, R. F.

AU - Beadling, Carol

PY - 1988

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AB - T-T tumor hybrids were constructed between the AKR SL3 thymoma and an H-2-distinguishable thymoma cell line. Hybrids were stimulated with IFN-γ to determine whether the differential augmentation of H-2D vs. H-2K class I antigen expression by AKR SL3 in response to IFN-γ was due to effects cis or trans to the noninducible K(k) gene. For each of a large number of hybrids tested, the expression of H-2D(b), K(b), and D(k), but not K(k), was substantially enhanced by murine rIFN-γ. These results suggested that the lack of induction of the K(k) gene was due to an alteration cis to K(k) rather than to the presence or absence of K region-specific, trans-acting negative or positive factors, respectively.

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