Differential expression of microRNA-320a, -145, and -192 along the continuum of normal mucosa to high-grade dysplastic adenomas of the colorectum

Vassiliki Tsikitis, Ian White, Motomi (Tomi) Mori, Amiee Potter, Achyut Bhattcharyya, Stanley R. Hamilton, Julie Buckmeier, Peter Lance, Patricia Thompson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: MicroRNA (miR)-320a, miR-145, and miR-192 have been shown to play a role in colorectal carcinogenesis and metastasis. We examined if there is a difference in expression during the histologic progression from normal mucosa (NM) to high-grade dysplastic adenomas (HG). Methods: Genome-wide miRNA expression profiling was performed on 113 colon adenomas. Information included histologic type, tumor grade, location, sex, age, family, and smoking history. A 2-way ANOVA was performed to evaluate the effect of the following factors adjusted for scan dates: location, sex, age, family history, smoking, and histology. Results: The expression of miR-320a increased; miR-145 and miR-192 expression decreased (P

Original languageEnglish (US)
Pages (from-to)717-722
Number of pages6
JournalAmerican Journal of Surgery
Volume207
Issue number5
DOIs
StatePublished - 2014

Fingerprint

MicroRNAs
Adenoma
Mucous Membrane
Smoking
Histology
Analysis of Variance
Colon
Carcinogenesis
History
Genome
Neoplasm Metastasis
Neoplasms

Keywords

  • Adenocarcinomas
  • Colorectal carcinogenesis and metastasis
  • High-grade dysplastic adenomas
  • MicroRNAs
  • miR expression

ASJC Scopus subject areas

  • Surgery

Cite this

Differential expression of microRNA-320a, -145, and -192 along the continuum of normal mucosa to high-grade dysplastic adenomas of the colorectum. / Tsikitis, Vassiliki; White, Ian; Mori, Motomi (Tomi); Potter, Amiee; Bhattcharyya, Achyut; Hamilton, Stanley R.; Buckmeier, Julie; Lance, Peter; Thompson, Patricia.

In: American Journal of Surgery, Vol. 207, No. 5, 2014, p. 717-722.

Research output: Contribution to journalArticle

Tsikitis, Vassiliki ; White, Ian ; Mori, Motomi (Tomi) ; Potter, Amiee ; Bhattcharyya, Achyut ; Hamilton, Stanley R. ; Buckmeier, Julie ; Lance, Peter ; Thompson, Patricia. / Differential expression of microRNA-320a, -145, and -192 along the continuum of normal mucosa to high-grade dysplastic adenomas of the colorectum. In: American Journal of Surgery. 2014 ; Vol. 207, No. 5. pp. 717-722.
@article{b7332adf609643e9a215c86278144de5,
title = "Differential expression of microRNA-320a, -145, and -192 along the continuum of normal mucosa to high-grade dysplastic adenomas of the colorectum",
abstract = "Background: MicroRNA (miR)-320a, miR-145, and miR-192 have been shown to play a role in colorectal carcinogenesis and metastasis. We examined if there is a difference in expression during the histologic progression from normal mucosa (NM) to high-grade dysplastic adenomas (HG). Methods: Genome-wide miRNA expression profiling was performed on 113 colon adenomas. Information included histologic type, tumor grade, location, sex, age, family, and smoking history. A 2-way ANOVA was performed to evaluate the effect of the following factors adjusted for scan dates: location, sex, age, family history, smoking, and histology. Results: The expression of miR-320a increased; miR-145 and miR-192 expression decreased (P",
keywords = "Adenocarcinomas, Colorectal carcinogenesis and metastasis, High-grade dysplastic adenomas, MicroRNAs, miR expression",
author = "Vassiliki Tsikitis and Ian White and Mori, {Motomi (Tomi)} and Amiee Potter and Achyut Bhattcharyya and Hamilton, {Stanley R.} and Julie Buckmeier and Peter Lance and Patricia Thompson",
year = "2014",
doi = "10.1016/j.amjsurg.2013.12.023",
language = "English (US)",
volume = "207",
pages = "717--722",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Differential expression of microRNA-320a, -145, and -192 along the continuum of normal mucosa to high-grade dysplastic adenomas of the colorectum

AU - Tsikitis, Vassiliki

AU - White, Ian

AU - Mori, Motomi (Tomi)

AU - Potter, Amiee

AU - Bhattcharyya, Achyut

AU - Hamilton, Stanley R.

AU - Buckmeier, Julie

AU - Lance, Peter

AU - Thompson, Patricia

PY - 2014

Y1 - 2014

N2 - Background: MicroRNA (miR)-320a, miR-145, and miR-192 have been shown to play a role in colorectal carcinogenesis and metastasis. We examined if there is a difference in expression during the histologic progression from normal mucosa (NM) to high-grade dysplastic adenomas (HG). Methods: Genome-wide miRNA expression profiling was performed on 113 colon adenomas. Information included histologic type, tumor grade, location, sex, age, family, and smoking history. A 2-way ANOVA was performed to evaluate the effect of the following factors adjusted for scan dates: location, sex, age, family history, smoking, and histology. Results: The expression of miR-320a increased; miR-145 and miR-192 expression decreased (P

AB - Background: MicroRNA (miR)-320a, miR-145, and miR-192 have been shown to play a role in colorectal carcinogenesis and metastasis. We examined if there is a difference in expression during the histologic progression from normal mucosa (NM) to high-grade dysplastic adenomas (HG). Methods: Genome-wide miRNA expression profiling was performed on 113 colon adenomas. Information included histologic type, tumor grade, location, sex, age, family, and smoking history. A 2-way ANOVA was performed to evaluate the effect of the following factors adjusted for scan dates: location, sex, age, family history, smoking, and histology. Results: The expression of miR-320a increased; miR-145 and miR-192 expression decreased (P

KW - Adenocarcinomas

KW - Colorectal carcinogenesis and metastasis

KW - High-grade dysplastic adenomas

KW - MicroRNAs

KW - miR expression

UR - http://www.scopus.com/inward/record.url?scp=84899768909&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899768909&partnerID=8YFLogxK

U2 - 10.1016/j.amjsurg.2013.12.023

DO - 10.1016/j.amjsurg.2013.12.023

M3 - Article

VL - 207

SP - 717

EP - 722

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

IS - 5

ER -