Differential effects of subcutaneous estrogen and progesterone on low- density lipoprotein size and susceptibility to oxidation in postmenopausal rhesus monkeys

Karen A. McKinney, Phillip E. Patton, P. Barton Duell, Harold G. Spies, David L. Wheaton, Kenneth A. Burry, David L. Hess

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Objective: To study the differential effects of subcutaneous E2 alone or in combination with P on the susceptibility of low-density lipoprotein (LDL) cholesterol to oxidation in naturally postmenopausal diet-controlled rhesus monkeys. Design: Prospective, longitudinal controlled study. Setting: Oregon Health Sciences University, Portland, Oregon, and Oregon Regional Primate Research Center, Beaverton, Oregon. Patient(s): Five naturally postmenopausal rhesus monkeys. Intervention(s): Estradiol was administered subcutaneously for the first 4 weeks, followed by E2 plus P for 4 weeks, followed by a third 4-week washout period. Main Outcome Measure(s): Changes in plasma lipoprotein levels and oxidation of LDL and serum concentrations of E2 and P. Result(s): Levels of LDL cholesterol fell after 4 weeks of treatment with E2, compared with baseline. The lag time to half maximal light absorbency after 4 weeks of E2 treatment was significantly increased compared with baseline. The maximal absorbance values and the slope of the propagation phase after 4 weeks of treatment with E2 were decreased compared with baseline. After 4 weeks of combined E2 and P treatment, all values were comparable to baseline. Conclusion(s): These results suggest that subcutaneous E2 therapy appears to enhance LDL resistance to oxidation and that this effect is attenuated by the addition of the P.

Original languageEnglish (US)
Pages (from-to)525-530
Number of pages6
JournalFertility and sterility
Volume68
Issue number3
DOIs
StatePublished - Sep 1997

Keywords

  • Estrogen
  • LDL oxidation
  • Menopause
  • Progesterone
  • Rhesus monkeys

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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