Differential effect of cocaine on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens: Comparison to amphetamine

Bita Moghaddam, Benhamin S. Bunney

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

The technique of in vivo microdialysis was used to measure the extracellular levels of dopamine in the nucleus accumbens septi and medial prefrontal cortex of chloral‐hydrate‐anaesthetized rats following systemic administration of cocaine and amphetamine. Intravenous injection of cocaine increased the extracellular levels of dopamine in the medial prefrontal cortex and the nucleus accumbens septi in a dose‐dependent manner. However, the magnitude of increase was significantly greater in nucleus accumbens than in medial prefrontal cortex. In comparison to cocaine, amphetamine increased the extracellular levels of dopamine in the nucleus accumbens and medial prefrontal cortex to the same degree. Based on the relatively small increase of extracellular dopamine levels in medial prefrontal cortex by cocaine, it is postulated that dopaminergic innervation of other structures besides medial prefrontal cortex may be involved in maintenance of cocaine self‐administration.

Original languageEnglish (US)
Pages (from-to)156-161
Number of pages6
JournalSynapse
Volume4
Issue number2
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Nucleus Accumbens
Amphetamine
Prefrontal Cortex
Cocaine
Dopamine
Microdialysis
Intravenous Injections
Maintenance

Keywords

  • Dopamine uptake
  • Microdialysis
  • Reward

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Differential effect of cocaine on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens : Comparison to amphetamine. / Moghaddam, Bita; Bunney, Benhamin S.

In: Synapse, Vol. 4, No. 2, 1989, p. 156-161.

Research output: Contribution to journalArticle

@article{8488f1247d5a4a77833f9844dd9bdc7a,
title = "Differential effect of cocaine on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens: Comparison to amphetamine",
abstract = "The technique of in vivo microdialysis was used to measure the extracellular levels of dopamine in the nucleus accumbens septi and medial prefrontal cortex of chloral‐hydrate‐anaesthetized rats following systemic administration of cocaine and amphetamine. Intravenous injection of cocaine increased the extracellular levels of dopamine in the medial prefrontal cortex and the nucleus accumbens septi in a dose‐dependent manner. However, the magnitude of increase was significantly greater in nucleus accumbens than in medial prefrontal cortex. In comparison to cocaine, amphetamine increased the extracellular levels of dopamine in the nucleus accumbens and medial prefrontal cortex to the same degree. Based on the relatively small increase of extracellular dopamine levels in medial prefrontal cortex by cocaine, it is postulated that dopaminergic innervation of other structures besides medial prefrontal cortex may be involved in maintenance of cocaine self‐administration.",
keywords = "Dopamine uptake, Microdialysis, Reward",
author = "Bita Moghaddam and Bunney, {Benhamin S.}",
year = "1989",
doi = "10.1002/syn.890040209",
language = "English (US)",
volume = "4",
pages = "156--161",
journal = "Synapse",
issn = "0887-4476",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Differential effect of cocaine on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens

T2 - Comparison to amphetamine

AU - Moghaddam, Bita

AU - Bunney, Benhamin S.

PY - 1989

Y1 - 1989

N2 - The technique of in vivo microdialysis was used to measure the extracellular levels of dopamine in the nucleus accumbens septi and medial prefrontal cortex of chloral‐hydrate‐anaesthetized rats following systemic administration of cocaine and amphetamine. Intravenous injection of cocaine increased the extracellular levels of dopamine in the medial prefrontal cortex and the nucleus accumbens septi in a dose‐dependent manner. However, the magnitude of increase was significantly greater in nucleus accumbens than in medial prefrontal cortex. In comparison to cocaine, amphetamine increased the extracellular levels of dopamine in the nucleus accumbens and medial prefrontal cortex to the same degree. Based on the relatively small increase of extracellular dopamine levels in medial prefrontal cortex by cocaine, it is postulated that dopaminergic innervation of other structures besides medial prefrontal cortex may be involved in maintenance of cocaine self‐administration.

AB - The technique of in vivo microdialysis was used to measure the extracellular levels of dopamine in the nucleus accumbens septi and medial prefrontal cortex of chloral‐hydrate‐anaesthetized rats following systemic administration of cocaine and amphetamine. Intravenous injection of cocaine increased the extracellular levels of dopamine in the medial prefrontal cortex and the nucleus accumbens septi in a dose‐dependent manner. However, the magnitude of increase was significantly greater in nucleus accumbens than in medial prefrontal cortex. In comparison to cocaine, amphetamine increased the extracellular levels of dopamine in the nucleus accumbens and medial prefrontal cortex to the same degree. Based on the relatively small increase of extracellular dopamine levels in medial prefrontal cortex by cocaine, it is postulated that dopaminergic innervation of other structures besides medial prefrontal cortex may be involved in maintenance of cocaine self‐administration.

KW - Dopamine uptake

KW - Microdialysis

KW - Reward

UR - http://www.scopus.com/inward/record.url?scp=0024466367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024466367&partnerID=8YFLogxK

U2 - 10.1002/syn.890040209

DO - 10.1002/syn.890040209

M3 - Article

C2 - 2781466

AN - SCOPUS:0024466367

VL - 4

SP - 156

EP - 161

JO - Synapse

JF - Synapse

SN - 0887-4476

IS - 2

ER -