Differential cross-sectional and longitudinal impact of APOE genotype on hippocampal volumes in nondemented older adults

Amy J. Jak; Wes S. Houston; Bonnie J. Nagel; Jody Corey-Bloom; Mark W. Bondi

doi:10.1159/000101340

Differential cross-sectional and longitudinal impact of APOE genotype on hippocampal volumes in nondemented older adults

Amy J. Jak, Wes S. Houston, Bonnie J. Nagel, Jody Corey-Bloom, Mark W. Bondi

Psychiatry

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

Background/Aims: Because of conflicting findings across studies, we sought to better determine the relationship between apolipoprotein E (APOE) genotype, hippocampal volume, and cognitive performance in nondemented older adults. Methods: Two groups ofolder adults, as determined by their APOE ε4 allele status, received structural MRI and comprehensive neuropsychological testing on two occasions separated on average by 17 months. Results: Cross-sectional comparisons by APOE group revealed no differences in hippocampal volumes, although longitudinal percent reduction in hippocampal volume was significantly greater for those possessing the APOE ε4 allele. Relationship between hippocampal volumes and memory performance was strongly impacted by diagnosis of mild cognitive impairment. Conclusions: APOE ε4 allele appears to significantly impact rate of volume loss over time in the hippocampus in nondemented older adults, and detailed cognitive characterization of the sample is necessary to reliably interpret the relationship between cognition and brain structure.

Original language	English (US)
Pages (from-to)	382-389
Number of pages	8
Journal	Dementia and geriatric cognitive disorders
Volume	23
Issue number	6
DOIs	https://doi.org/10.1159/000101340
State	Published - May 2007

Keywords

Apolipoprotein E ε4 allele
Cognitive performance
Hippocampal volume

ASJC Scopus subject areas

Geriatrics and Gerontology
Cognitive Neuroscience
Psychiatry and Mental health

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10.1159/000101340

Cite this

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abstract = "Background/Aims: Because of conflicting findings across studies, we sought to better determine the relationship between apolipoprotein E (APOE) genotype, hippocampal volume, and cognitive performance in nondemented older adults. Methods: Two groups ofolder adults, as determined by their APOE ε4 allele status, received structural MRI and comprehensive neuropsychological testing on two occasions separated on average by 17 months. Results: Cross-sectional comparisons by APOE group revealed no differences in hippocampal volumes, although longitudinal percent reduction in hippocampal volume was significantly greater for those possessing the APOE ε4 allele. Relationship between hippocampal volumes and memory performance was strongly impacted by diagnosis of mild cognitive impairment. Conclusions: APOE ε4 allele appears to significantly impact rate of volume loss over time in the hippocampus in nondemented older adults, and detailed cognitive characterization of the sample is necessary to reliably interpret the relationship between cognition and brain structure.",

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AU - Nagel, Bonnie J.

AU - Corey-Bloom, Jody

AU - Bondi, Mark W.

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N2 - Background/Aims: Because of conflicting findings across studies, we sought to better determine the relationship between apolipoprotein E (APOE) genotype, hippocampal volume, and cognitive performance in nondemented older adults. Methods: Two groups ofolder adults, as determined by their APOE ε4 allele status, received structural MRI and comprehensive neuropsychological testing on two occasions separated on average by 17 months. Results: Cross-sectional comparisons by APOE group revealed no differences in hippocampal volumes, although longitudinal percent reduction in hippocampal volume was significantly greater for those possessing the APOE ε4 allele. Relationship between hippocampal volumes and memory performance was strongly impacted by diagnosis of mild cognitive impairment. Conclusions: APOE ε4 allele appears to significantly impact rate of volume loss over time in the hippocampus in nondemented older adults, and detailed cognitive characterization of the sample is necessary to reliably interpret the relationship between cognition and brain structure.

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Differential cross-sectional and longitudinal impact of APOE genotype on hippocampal volumes in nondemented older adults

Abstract

Keywords

ASJC Scopus subject areas

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