Differential antigen presentation kinetics of CD8+ T-cell epitopes derived from the same viral protein

Jonah Sacha, Matthew R. Reynolds, Matthew B. Buechler, Won Chung, Anna K. Jonas, Lyle T. Wallace, Andrea M. Weiler, Wonhee Lee, Shari M. Piaskowski, Taeko Soma, Thomas C. Friedrich, Nancy A. Wilson, David I. Watkins

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The kinetics of peptide presentation by major histocompatibility complex class I (MHC-I) molecules may contribute to the efficacy of CD8+ T cells. Whether all CD8+ T-cell epitopes from a protein are presented by the same MHC-I molecule with similar kinetics is unknown. Here we show that CD8+ T-cell epitopes derived from SIVmac239 Gag are presented with markedly different kinetics. We demonstrate that this discrepancy in presentation is not related to immunodominance but instead is due to differential requirements for epitope generation. These results illustrate that significant differences in presentation kinetics can exist among CD8+ T-cell epitopes derived from the same viral protein.

Original languageEnglish (US)
Pages (from-to)9293-9298
Number of pages6
JournalJournal of Virology
Volume82
Issue number18
DOIs
StatePublished - Sep 2008
Externally publishedYes

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antigen presentation
T-Lymphocyte Epitopes
viral proteins
Antigen Presentation
Viral Proteins
epitopes
T-lymphocytes
kinetics
major histocompatibility complex
Major Histocompatibility Complex
Epitopes
peptides
T-Lymphocytes
Peptides
Proteins
proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Sacha, J., Reynolds, M. R., Buechler, M. B., Chung, W., Jonas, A. K., Wallace, L. T., ... Watkins, D. I. (2008). Differential antigen presentation kinetics of CD8+ T-cell epitopes derived from the same viral protein. Journal of Virology, 82(18), 9293-9298. https://doi.org/10.1128/JVI.00749-08

Differential antigen presentation kinetics of CD8+ T-cell epitopes derived from the same viral protein. / Sacha, Jonah; Reynolds, Matthew R.; Buechler, Matthew B.; Chung, Won; Jonas, Anna K.; Wallace, Lyle T.; Weiler, Andrea M.; Lee, Wonhee; Piaskowski, Shari M.; Soma, Taeko; Friedrich, Thomas C.; Wilson, Nancy A.; Watkins, David I.

In: Journal of Virology, Vol. 82, No. 18, 09.2008, p. 9293-9298.

Research output: Contribution to journalArticle

Sacha, J, Reynolds, MR, Buechler, MB, Chung, W, Jonas, AK, Wallace, LT, Weiler, AM, Lee, W, Piaskowski, SM, Soma, T, Friedrich, TC, Wilson, NA & Watkins, DI 2008, 'Differential antigen presentation kinetics of CD8+ T-cell epitopes derived from the same viral protein', Journal of Virology, vol. 82, no. 18, pp. 9293-9298. https://doi.org/10.1128/JVI.00749-08
Sacha, Jonah ; Reynolds, Matthew R. ; Buechler, Matthew B. ; Chung, Won ; Jonas, Anna K. ; Wallace, Lyle T. ; Weiler, Andrea M. ; Lee, Wonhee ; Piaskowski, Shari M. ; Soma, Taeko ; Friedrich, Thomas C. ; Wilson, Nancy A. ; Watkins, David I. / Differential antigen presentation kinetics of CD8+ T-cell epitopes derived from the same viral protein. In: Journal of Virology. 2008 ; Vol. 82, No. 18. pp. 9293-9298.
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