Abstract
Two new complementary DNAs overlapping cDNA clones that encode the G-protein coupled metabotropic glutamate receptor mGluRT from rat brain have been isolated and sequenced in their entirety. These new clones represent mRNA with 3' untranslated regions ∼2.5 kilobases longer than the previously isolated cDNA clones. These results indicate that the previously observed two size classes of ∼4 kb and ∼7 kb which hybridize to sequences that encode this receptor use different polyadenylation signals and differ in the extent of their 3' untranslated sequence. There is a striking asymmetry in the distribution of a sequence involved in mRNA instability between the two mRNA species.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 53-57 |
| Number of pages | 5 |
| Journal | Mitochondrial DNA |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1993 |
Keywords
- CDNA
- MRNA
- Metabotropic glutamate receptor
- Polyadenylation
ASJC Scopus subject areas
- Molecular Biology
- Genetics
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Cite this
O'hara, P. J., Gilbert, T. L., Haldeman, B. A., Houamed, K. M., Kuijper, J. L., Hagen, F. S., Almers, W., & Mulvihill, E. (1993). Different sites of polyadenylation in mRNAs encoding a rat metabotropic glutamate receptor. Mitochondrial DNA, 4(1), 53-57. https://doi.org/10.3109/10425179309015623