Abstract
Two new complementary DNAs overlapping cDNA clones that encode the G-protein coupled metabotropic glutamate receptor mGluRT from rat brain have been isolated and sequenced in their entirety. These new clones represent mRNA with 3' untranslated regions ∼2.5 kilobases longer than the previously isolated cDNA clones. These results indicate that the previously observed two size classes of ∼4 kb and ∼7 kb which hybridize to sequences that encode this receptor use different polyadenylation signals and differ in the extent of their 3' untranslated sequence. There is a striking asymmetry in the distribution of a sequence involved in mRNA instability between the two mRNA species.
Original language | English (US) |
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Pages (from-to) | 53-57 |
Number of pages | 5 |
Journal | Mitochondrial DNA |
Volume | 4 |
Issue number | 1 |
DOIs | |
State | Published - 1993 |
Externally published | Yes |
Keywords
- CDNA
- MRNA
- Metabotropic glutamate receptor
- Polyadenylation
ASJC Scopus subject areas
- Molecular Biology
- Genetics