Two new complementary DNAs overlapping cDNA clones that encode the G-protein coupled metabotropic glutamate receptor mGluRT from rat brain have been isolated and sequenced in their entirety. These new clones represent mRNA with 3' untranslated regions ∼2.5 kilobases longer than the previously isolated cDNA clones. These results indicate that the previously observed two size classes of ∼4 kb and ∼7 kb which hybridize to sequences that encode this receptor use different polyadenylation signals and differ in the extent of their 3' untranslated sequence. There is a striking asymmetry in the distribution of a sequence involved in mRNA instability between the two mRNA species.
- Metabotropic glutamate receptor
ASJC Scopus subject areas
- Molecular Biology