Different sites of polyadenylation in mRNAs encoding a rat metabotropic glutamate receptor

P. J. O'hara, T. L. Gilbert, B. A. Haldeman, K. M. Houamed, J. L. Kuijper, F. S. Hagen, W. Almers, E. Mulvihill

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Abstract

Two new complementary DNAs overlapping cDNA clones that encode the G-protein coupled metabotropic glutamate receptor mGluRT from rat brain have been isolated and sequenced in their entirety. These new clones represent mRNA with 3' untranslated regions ∼2.5 kilobases longer than the previously isolated cDNA clones. These results indicate that the previously observed two size classes of ∼4 kb and ∼7 kb which hybridize to sequences that encode this receptor use different polyadenylation signals and differ in the extent of their 3' untranslated sequence. There is a striking asymmetry in the distribution of a sequence involved in mRNA instability between the two mRNA species.

Original languageEnglish (US)
Pages (from-to)53-57
Number of pages5
JournalMitochondrial DNA
Volume4
Issue number1
DOIs
StatePublished - Jan 1 1993

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Keywords

  • CDNA
  • MRNA
  • Metabotropic glutamate receptor
  • Polyadenylation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

O'hara, P. J., Gilbert, T. L., Haldeman, B. A., Houamed, K. M., Kuijper, J. L., Hagen, F. S., Almers, W., & Mulvihill, E. (1993). Different sites of polyadenylation in mRNAs encoding a rat metabotropic glutamate receptor. Mitochondrial DNA, 4(1), 53-57. https://doi.org/10.3109/10425179309015623