Different sites of polyadenylation in mRNAs encoding a rat metabotropic glutamate receptor

P. J. O'hara; T. L. Gilbert; B. A. Haldeman; K. M. Houamed; J. L. Kuijper; F. S. Hagen; W. Almers; E. Mulvihill

doi:10.3109/10425179309015623

Different sites of polyadenylation in mRNAs encoding a rat metabotropic glutamate receptor

P. J. O'hara, T. L. Gilbert, B. A. Haldeman, K. M. Houamed, J. L. Kuijper, F. S. Hagen, W. Almers, E. Mulvihill

Vollum Institute

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

Two new complementary DNAs overlapping cDNA clones that encode the G-protein coupled metabotropic glutamate receptor mGluRT from rat brain have been isolated and sequenced in their entirety. These new clones represent mRNA with 3' untranslated regions ∼2.5 kilobases longer than the previously isolated cDNA clones. These results indicate that the previously observed two size classes of ∼4 kb and ∼7 kb which hybridize to sequences that encode this receptor use different polyadenylation signals and differ in the extent of their 3' untranslated sequence. There is a striking asymmetry in the distribution of a sequence involved in mRNA instability between the two mRNA species.

Original language	English (US)
Pages (from-to)	53-57
Number of pages	5
Journal	Mitochondrial DNA
Volume	4
Issue number	1
DOIs	https://doi.org/10.3109/10425179309015623
State	Published - Jan 1 1993

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Keywords

CDNA
MRNA
Metabotropic glutamate receptor
Polyadenylation

ASJC Scopus subject areas

Molecular Biology
Genetics

Cite this

O'hara, P. J., Gilbert, T. L., Haldeman, B. A., Houamed, K. M., Kuijper, J. L., Hagen, F. S., Almers, W., & Mulvihill, E. (1993). Different sites of polyadenylation in mRNAs encoding a rat metabotropic glutamate receptor. Mitochondrial DNA, 4(1), 53-57. https://doi.org/10.3109/10425179309015623

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AU - Kuijper, J. L.

AU - Hagen, F. S.

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10.3109/10425179309015623