Different MAF translocations confer similar prognosis in newly diagnosed multiple myeloma patients

Sarah Goldman-Mazur, Artur Jurczyszyn, Jorge J. Castillo, Anna Waszczuk-Gajda, Norbert Grząśko, Jakub Radocha, Max Bittrich, Klaus Martin Kortüm, Alessandro Gozzetti, Lidia Usnarska-Zubkiewicz, Julio D. Valls, David S. Jayabalan, Ruben Niesvizky, Julia Kelman, Daniel Coriu, Laura Rosiñol, Łukasz Szukalski, Veronica González-Calle, María Victoria Mateos, Krzysztof JamroziakIwona Hus, Irit Avivi, Yael Cohen, Piotr Mazur, Anna Suska, Aimee Chappell, Deepu Madduri, Saurabh Chhabra, Ariel Kleman, Parameswaran Hari, Michel Delforge, Paweł Robak, Massimo Gentile, Izabela Kozłowska, Stuart L. Goldberg, Jacek Czepiel, Monika Długosz-Danecka, Rebecca Silbermann, Adam J. Olszewski, Peter Barth, Gabor Mikala, Chor S. Chim, David H. Vesole

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The MAF translocations, t(14;16) and t(14;20), are considered as adverse prognostic factors based on few studies with small sample sizes. We report on their prognostic impact in a large group of 254 patients–223 (87.8%) with t(14;16) and 31 (12.2%) with t(14;20). There were no intergroup differences in survival estimates. Median progression-free survival was 16.6 months for t(14;16) and 24.9 months for t(14;20) (p = 0.28). Median overall survival (OS) was 54.0 months and 49.0 months, respectively (p = 0.62). Median OS in patients who underwent double autologous stem cell transplantation (ASCT) was 107.0 months versus 60.0 months in patients who received single ASCT (p < 0.001). ISS 3 was associated with shorter OS (HR = 1.89; 95% CI 1.24–3.19; p = 0.005) in Cox analysis. Our study suggests that t(14;20) should be considered as an adverse factor of equal prognostic implication to t(14;16).

Original languageEnglish (US)
Pages (from-to)1885-1893
Number of pages9
JournalLeukemia and Lymphoma
Volume61
Issue number8
DOIs
StatePublished - Jul 2 2020

Keywords

  • MAF
  • Translocation
  • myeloma
  • survival
  • t(14;16)
  • t(14;20)

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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