Differences in the motor response to apomorphine between untreated and fluctuating patients with Parkinson's disease

F. Grandas, S. T. Gancher, M. Rodriguez, G. Lera, John Nutt, J. A. Obeso

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Behavioral hyposensitivity to repeated apomorphine administration has been observed in fluctuating parkinsonian patients. To investigate whether a similar phenomenon occurs in patients never treated with levodopa, we studied the response to apomorphine in 20 de novo patients with Parkinson's disease. Six patients showed no or minimal improvement after apomorphine injections (maximal dose 3.5 mg). Fourteen patients responded and were then given up to four repeated subcutaneous injections of apomorphine [minimal effective dose (MED)]. The responses of de novo patients were compared with responses in 10 patients with motor fluctuations previously studied by the same protocol. There was no significant difference in latency and duration of motor responses after repeated apomorphine injections in de novo patients. MED was similar in de novo and fluctuating patients, but duration of improvement induced by each apomorphine bolus was longer in the de novo group. These results indicate that response duration to apomorphine is longer in previously untreated patients and that behavioral tolerance associated with pulsatile dopaminergic stimulation by apomorphine occurs mainly in patients with more advanced disease under chronic levodopa therapy.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalClinical Neuropharmacology
Volume15
Issue number1
StatePublished - 1992
Externally publishedYes

Fingerprint

Apomorphine
Parkinson Disease
Levodopa
Injections
Subcutaneous Injections
Chronic Disease

Keywords

  • Apomorphine
  • Motor fluctuations
  • Untreated Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Differences in the motor response to apomorphine between untreated and fluctuating patients with Parkinson's disease. / Grandas, F.; Gancher, S. T.; Rodriguez, M.; Lera, G.; Nutt, John; Obeso, J. A.

In: Clinical Neuropharmacology, Vol. 15, No. 1, 1992, p. 13-18.

Research output: Contribution to journalArticle

Grandas, F. ; Gancher, S. T. ; Rodriguez, M. ; Lera, G. ; Nutt, John ; Obeso, J. A. / Differences in the motor response to apomorphine between untreated and fluctuating patients with Parkinson's disease. In: Clinical Neuropharmacology. 1992 ; Vol. 15, No. 1. pp. 13-18.
@article{f5c3bbd8dda64acaa324be0b7cdd8885,
title = "Differences in the motor response to apomorphine between untreated and fluctuating patients with Parkinson's disease",
abstract = "Behavioral hyposensitivity to repeated apomorphine administration has been observed in fluctuating parkinsonian patients. To investigate whether a similar phenomenon occurs in patients never treated with levodopa, we studied the response to apomorphine in 20 de novo patients with Parkinson's disease. Six patients showed no or minimal improvement after apomorphine injections (maximal dose 3.5 mg). Fourteen patients responded and were then given up to four repeated subcutaneous injections of apomorphine [minimal effective dose (MED)]. The responses of de novo patients were compared with responses in 10 patients with motor fluctuations previously studied by the same protocol. There was no significant difference in latency and duration of motor responses after repeated apomorphine injections in de novo patients. MED was similar in de novo and fluctuating patients, but duration of improvement induced by each apomorphine bolus was longer in the de novo group. These results indicate that response duration to apomorphine is longer in previously untreated patients and that behavioral tolerance associated with pulsatile dopaminergic stimulation by apomorphine occurs mainly in patients with more advanced disease under chronic levodopa therapy.",
keywords = "Apomorphine, Motor fluctuations, Untreated Parkinson's disease",
author = "F. Grandas and Gancher, {S. T.} and M. Rodriguez and G. Lera and John Nutt and Obeso, {J. A.}",
year = "1992",
language = "English (US)",
volume = "15",
pages = "13--18",
journal = "Clinical Neuropharmacology",
issn = "0362-5664",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Differences in the motor response to apomorphine between untreated and fluctuating patients with Parkinson's disease

AU - Grandas, F.

AU - Gancher, S. T.

AU - Rodriguez, M.

AU - Lera, G.

AU - Nutt, John

AU - Obeso, J. A.

PY - 1992

Y1 - 1992

N2 - Behavioral hyposensitivity to repeated apomorphine administration has been observed in fluctuating parkinsonian patients. To investigate whether a similar phenomenon occurs in patients never treated with levodopa, we studied the response to apomorphine in 20 de novo patients with Parkinson's disease. Six patients showed no or minimal improvement after apomorphine injections (maximal dose 3.5 mg). Fourteen patients responded and were then given up to four repeated subcutaneous injections of apomorphine [minimal effective dose (MED)]. The responses of de novo patients were compared with responses in 10 patients with motor fluctuations previously studied by the same protocol. There was no significant difference in latency and duration of motor responses after repeated apomorphine injections in de novo patients. MED was similar in de novo and fluctuating patients, but duration of improvement induced by each apomorphine bolus was longer in the de novo group. These results indicate that response duration to apomorphine is longer in previously untreated patients and that behavioral tolerance associated with pulsatile dopaminergic stimulation by apomorphine occurs mainly in patients with more advanced disease under chronic levodopa therapy.

AB - Behavioral hyposensitivity to repeated apomorphine administration has been observed in fluctuating parkinsonian patients. To investigate whether a similar phenomenon occurs in patients never treated with levodopa, we studied the response to apomorphine in 20 de novo patients with Parkinson's disease. Six patients showed no or minimal improvement after apomorphine injections (maximal dose 3.5 mg). Fourteen patients responded and were then given up to four repeated subcutaneous injections of apomorphine [minimal effective dose (MED)]. The responses of de novo patients were compared with responses in 10 patients with motor fluctuations previously studied by the same protocol. There was no significant difference in latency and duration of motor responses after repeated apomorphine injections in de novo patients. MED was similar in de novo and fluctuating patients, but duration of improvement induced by each apomorphine bolus was longer in the de novo group. These results indicate that response duration to apomorphine is longer in previously untreated patients and that behavioral tolerance associated with pulsatile dopaminergic stimulation by apomorphine occurs mainly in patients with more advanced disease under chronic levodopa therapy.

KW - Apomorphine

KW - Motor fluctuations

KW - Untreated Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=0026565369&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026565369&partnerID=8YFLogxK

M3 - Article

C2 - 1576595

AN - SCOPUS:0026565369

VL - 15

SP - 13

EP - 18

JO - Clinical Neuropharmacology

JF - Clinical Neuropharmacology

SN - 0362-5664

IS - 1

ER -