Differences in regional brain metabolic responses between single and repeated doses of methylphenidate

Nora D. Volkow; Gene Jack Wang; Joanna S. Fowler; Robert Hitzemann; John Gatley; Yu Shin Ding; Christopher Wong; Naome Pappas

doi:10.1016/S0925-4927(98)00025-0

Differences in regional brain metabolic responses between single and repeated doses of methylphenidate

Nora D. Volkow, Gene Jack Wang, Joanna S. Fowler, Robert Hitzemann, John Gatley, Yu Shin Ding, Christopher Wong, Naome Pappas

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Studies investigating the acute effects of drugs of abuse on human brain metabolism have measured single doses whereas these drugs are mostly taken repeatedly. Here we compared the brain metabolic response to intravenous methylphenidate when given after a single dose to that when given after two sequential doses. Methylphenidate-induced changes in metabolism differed; whereas single doses tended to decrease metabolism, repeated doses tended to increase it, and these differences were significant in frontal, parietal and occipital cortices and hippocampus. This indicates that methylphenidate's metabolic effects vary with acute previous exposure and highlights the importance of studying drugs after single and repeated administration.

Original language	English (US)
Pages (from-to)	29-36
Number of pages	8
Journal	Psychiatry Research - Neuroimaging
Volume	83
Issue number	1
DOIs	https://doi.org/10.1016/S0925-4927(98)00025-0
State	Published - Jul 15 1998
Externally published	Yes

Keywords

Bingeing
Cocaine
Craving
Dopamine
Drug addiction
FDG
PET

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

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10.1016/S0925-4927(98)00025-0

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title = "Differences in regional brain metabolic responses between single and repeated doses of methylphenidate",

abstract = "Studies investigating the acute effects of drugs of abuse on human brain metabolism have measured single doses whereas these drugs are mostly taken repeatedly. Here we compared the brain metabolic response to intravenous methylphenidate when given after a single dose to that when given after two sequential doses. Methylphenidate-induced changes in metabolism differed; whereas single doses tended to decrease metabolism, repeated doses tended to increase it, and these differences were significant in frontal, parietal and occipital cortices and hippocampus. This indicates that methylphenidate's metabolic effects vary with acute previous exposure and highlights the importance of studying drugs after single and repeated administration.",

keywords = "Bingeing, Cocaine, Craving, Dopamine, Drug addiction, FDG, PET",

author = "Volkow, {Nora D.} and Wang, {Gene Jack} and Fowler, {Joanna S.} and Robert Hitzemann and John Gatley and Ding, {Yu Shin} and Christopher Wong and Naome Pappas",

note = "Funding Information: This research was supported in part by the US Department of Energy (office of Health and Environmental Research) under Contract DE-ACO2-76CH00016 and the Institute of Drug Abuse under Grant No. DA06891. The authors thank David Alexoff, Robert Carciello, Richard Ferrieri, Payton King, Alex Levy, Robert MacGregor, Noelwah Netusil, Katy Pascani, Carol Redvanly, David Schlyer, Colleen Shea, and Donald Warner for advice and assistance. ",

year = "1998",

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day = "15",

doi = "10.1016/S0925-4927(98)00025-0",

language = "English (US)",

volume = "83",

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T1 - Differences in regional brain metabolic responses between single and repeated doses of methylphenidate

AU - Volkow, Nora D.

AU - Wang, Gene Jack

AU - Fowler, Joanna S.

AU - Hitzemann, Robert

AU - Gatley, John

AU - Ding, Yu Shin

AU - Wong, Christopher

AU - Pappas, Naome

N1 - Funding Information: This research was supported in part by the US Department of Energy (office of Health and Environmental Research) under Contract DE-ACO2-76CH00016 and the Institute of Drug Abuse under Grant No. DA06891. The authors thank David Alexoff, Robert Carciello, Richard Ferrieri, Payton King, Alex Levy, Robert MacGregor, Noelwah Netusil, Katy Pascani, Carol Redvanly, David Schlyer, Colleen Shea, and Donald Warner for advice and assistance.

PY - 1998/7/15

Y1 - 1998/7/15

N2 - Studies investigating the acute effects of drugs of abuse on human brain metabolism have measured single doses whereas these drugs are mostly taken repeatedly. Here we compared the brain metabolic response to intravenous methylphenidate when given after a single dose to that when given after two sequential doses. Methylphenidate-induced changes in metabolism differed; whereas single doses tended to decrease metabolism, repeated doses tended to increase it, and these differences were significant in frontal, parietal and occipital cortices and hippocampus. This indicates that methylphenidate's metabolic effects vary with acute previous exposure and highlights the importance of studying drugs after single and repeated administration.

AB - Studies investigating the acute effects of drugs of abuse on human brain metabolism have measured single doses whereas these drugs are mostly taken repeatedly. Here we compared the brain metabolic response to intravenous methylphenidate when given after a single dose to that when given after two sequential doses. Methylphenidate-induced changes in metabolism differed; whereas single doses tended to decrease metabolism, repeated doses tended to increase it, and these differences were significant in frontal, parietal and occipital cortices and hippocampus. This indicates that methylphenidate's metabolic effects vary with acute previous exposure and highlights the importance of studying drugs after single and repeated administration.

KW - Bingeing

KW - Cocaine

KW - Craving

KW - Dopamine

KW - Drug addiction

KW - FDG

KW - PET

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ER -

Differences in regional brain metabolic responses between single and repeated doses of methylphenidate

Abstract

Keywords

ASJC Scopus subject areas

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