Differences between perinatal angiotensin binding in the brains of SHR and WKY rats

Vickie I. Cook, Kevin L. Grove, Robert C. Speth, Kathleen M. McMenamin, Joseph W. Harding

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    Abstract

    A growing body of evidence suggests that angiotensin may have a functional role in growth and development, in addition to its classical role in the maintenance of body water homeostasis. Components of the renin-angiotensin system have been identified in the rat fetus. Because of the association between the renin-angiotensin system and hypertension, we quantified angiotensin receptor binding sites in the brains of spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats during perinatal development. Using in vitro receptor autoradiography we identified specific 125I-Sar1,Ile8 AII binding in several areas of the brains of perinatal rats of both strains and observed significant differences in the concentration of binding sites, at different ages in several brain nuclei. With the knowledge that components of the renin-angiotensin system appear early in development and are known to have an association with cellular growth, it is possible that an irregularity in this system occurring during neurogenesis could contribute to developmental abnormalities, as well as subsequent hypertension.

    Original languageEnglish (US)
    Pages (from-to)395-405
    Number of pages11
    JournalRegulatory Peptides
    Volume45
    Issue number3
    DOIs
    StatePublished - Jun 11 1993

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    Keywords

    • Angiotensin receptor
    • Autoradiography
    • Brain
    • Perinatal
    • Spontaneously hypertensive rat

    ASJC Scopus subject areas

    • Biochemistry
    • Physiology
    • Endocrinology
    • Clinical Biochemistry
    • Cellular and Molecular Neuroscience

    Cite this

    Cook, V. I., Grove, K. L., Speth, R. C., McMenamin, K. M., & Harding, J. W. (1993). Differences between perinatal angiotensin binding in the brains of SHR and WKY rats. Regulatory Peptides, 45(3), 395-405. https://doi.org/10.1016/0167-0115(93)90366-G