Dietary risk factors for invasive and in-situ cervical carcinomas in Bangkok, Thailand

Jackilen (Jackie) Shannon, David B. Thomas, Roberta M. Ray, Mark Kestin, Amorn Koetsawang, Suporn Koetsawang, Kamolthip Chitnarong, Nancy Kiviat, Jane Kuypers

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Objective: Although human papillomavirus (HPV) may be a necessary cause of cervical cancer, most women with HPV infections do not develop this disease. This study was conducted to evaluate the possible effects of specific dietary factors on cervical carcinogenesis. Methods: Fifty hospitalized in-situ cases and 125 controls were identified from family planning or gynecologic clinics associated with Siriraj hospital in Bangkok, Thailand, and 134 hospitalized invasive cases and 384 hospitalized controls from the public wards of Siriraj Hospital were administered a food-frequency questionnaire and tested for HPV DNA in exfoliated cervical cells. Odds ratios in relation to intake of foods high in vitamin C, folate, vitamin E, vitamin A, β-carotene, retinol, and cruciferous vegetables were estimated using logistic regression in case-control comparisons and in case-case comparisons adjusted for HPV status. Results: High intake of foods rich in vitamin A, and particularly high-retinol foods, were associated with a reduced risk of in-situ disease and less strongly also with a reduced risk of invasive as compared to in-situ disease. No association was found between intake of cruciferous vegetables, foods high in vitamin C, folate, vitamin E, and β-carotene and risk of either in-situ or invasive cervical cancer. Conclusions: Increasing intake of foods rich in total vitamin A, and particularly high-retinol foods, may reduce risk of in-situ cervical cancer, and at the highest level of intake may inhibit progression to invasion. If others confirm these results they suggest means of reducing the risk of cervical cancer that are amenable to public health action.

Original languageEnglish (US)
Pages (from-to)691-699
Number of pages9
JournalCancer Causes and Control
Volume13
Issue number8
DOIs
StatePublished - Oct 2002
Externally publishedYes

Fingerprint

Carcinoma in Situ
Thailand
Vitamin A
Uterine Cervical Neoplasms
Food
Eating
Carotenoids
Folic Acid
Vegetables
Ascorbic Acid
Papillomavirus Infections
Family Planning Services
Vitamin E
Carcinogenesis
Public Health
Logistic Models
Odds Ratio
DNA

Keywords

  • Cancer
  • Nutrition
  • Prevention research

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Shannon, J. J., Thomas, D. B., Ray, R. M., Kestin, M., Koetsawang, A., Koetsawang, S., ... Kuypers, J. (2002). Dietary risk factors for invasive and in-situ cervical carcinomas in Bangkok, Thailand. Cancer Causes and Control, 13(8), 691-699. https://doi.org/10.1023/A:1020289618161

Dietary risk factors for invasive and in-situ cervical carcinomas in Bangkok, Thailand. / Shannon, Jackilen (Jackie); Thomas, David B.; Ray, Roberta M.; Kestin, Mark; Koetsawang, Amorn; Koetsawang, Suporn; Chitnarong, Kamolthip; Kiviat, Nancy; Kuypers, Jane.

In: Cancer Causes and Control, Vol. 13, No. 8, 10.2002, p. 691-699.

Research output: Contribution to journalArticle

Shannon, JJ, Thomas, DB, Ray, RM, Kestin, M, Koetsawang, A, Koetsawang, S, Chitnarong, K, Kiviat, N & Kuypers, J 2002, 'Dietary risk factors for invasive and in-situ cervical carcinomas in Bangkok, Thailand', Cancer Causes and Control, vol. 13, no. 8, pp. 691-699. https://doi.org/10.1023/A:1020289618161
Shannon JJ, Thomas DB, Ray RM, Kestin M, Koetsawang A, Koetsawang S et al. Dietary risk factors for invasive and in-situ cervical carcinomas in Bangkok, Thailand. Cancer Causes and Control. 2002 Oct;13(8):691-699. https://doi.org/10.1023/A:1020289618161
Shannon, Jackilen (Jackie) ; Thomas, David B. ; Ray, Roberta M. ; Kestin, Mark ; Koetsawang, Amorn ; Koetsawang, Suporn ; Chitnarong, Kamolthip ; Kiviat, Nancy ; Kuypers, Jane. / Dietary risk factors for invasive and in-situ cervical carcinomas in Bangkok, Thailand. In: Cancer Causes and Control. 2002 ; Vol. 13, No. 8. pp. 691-699.
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