Dietary pyrrolizidine (Senecio) alkaloids and tissue distribution of copper and vitamin A in broiler chickens

Jianya Huan, Peter R. Cheeke, Robert R. Lowry, Harry S. Nakaue, Stanley P. Snyder, Philip D. Whanger

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effect of feeding a diet containing 5% tansy ragwort (TR) (Senecio jacobaea), a poisonous plant containing pyrrolizidine alkaloids (PA), on the blood and liver levels of copper, zinc, iron and vitamin A in broiler chicks was examined. Serum and liver copper and liver iron concentrations were increased in chicks fed a diet with 5% TR, while serum and liver zinc and vitamin A decreased. When PA were removed from the diet, partial restoration of normal serum vitamin A level occurred, indicating that the ability to mobilize liver vitamin A is not irreversibly inhibited by PA. The decline in serum vitamin A occurred by 8 days of TR feeding with a concurrent decline in growth rate. When chicks were fed a diet high in vitamin A (25 000 IU/kg), followed by a basal diet containing TR, serum vitamin A levels were significantly (P

Original languageEnglish (US)
Pages (from-to)139-153
Number of pages15
JournalToxicology Letters
Volume62
Issue number2-3
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Pyrrolizidine Alkaloids
Senecio
Tissue Distribution
Vitamin A
Tanacetum
Copper
Chickens
Nutrition
Tissue
Liver
Diet
Serum
Zinc
Iron
Toxic Plants
Restoration
Blood
Growth

Keywords

  • Chick
  • Copper
  • Pyrrolizidine alkaloid
  • Senecio jacobaea
  • Vitamin A

ASJC Scopus subject areas

  • Toxicology

Cite this

Huan, J., Cheeke, P. R., Lowry, R. R., Nakaue, H. S., Snyder, S. P., & Whanger, P. D. (1992). Dietary pyrrolizidine (Senecio) alkaloids and tissue distribution of copper and vitamin A in broiler chickens. Toxicology Letters, 62(2-3), 139-153. https://doi.org/10.1016/0378-4274(92)90017-E

Dietary pyrrolizidine (Senecio) alkaloids and tissue distribution of copper and vitamin A in broiler chickens. / Huan, Jianya; Cheeke, Peter R.; Lowry, Robert R.; Nakaue, Harry S.; Snyder, Stanley P.; Whanger, Philip D.

In: Toxicology Letters, Vol. 62, No. 2-3, 1992, p. 139-153.

Research output: Contribution to journalArticle

Huan, Jianya ; Cheeke, Peter R. ; Lowry, Robert R. ; Nakaue, Harry S. ; Snyder, Stanley P. ; Whanger, Philip D. / Dietary pyrrolizidine (Senecio) alkaloids and tissue distribution of copper and vitamin A in broiler chickens. In: Toxicology Letters. 1992 ; Vol. 62, No. 2-3. pp. 139-153.
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