Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys

Martha Neuringer, W. E. Connor, C. Van Petten, L. Barstad

    Research output: Contribution to journalArticle

    480 Citations (Scopus)

    Abstract

    Linolenic acid (18:3ω3) is a dietary precursor of docosahexaenoic acid (22:6ω3), the major fatty acid in the photoreceptor membranes of the retina. We hypothesized that rhesus monkeys deprived of dietary ω-3 fatty acids during prenatal and postnatal development would show plasma depletion of these fatty acids and visual impairment. Semipurified diets low in ω-3 fatty acids were fed to one group of adult female rhesus monkeys throughout pregnancy and to their infants from birth. A control group of mothers and infants received similar diets but supplying ample linolenic acid. In the plasma phospholipids of deficient infants, linolenic acid was generally undetectable and 22:6ω3 levels became progressively depleted, falling from 42% of control values at birth to 21% at 4 wk, 9% at 8 wk, and 6% at 12 wk of age. In the other plasma lipid classes, 22:6ω3 was undetectable by 12 wk. The visual acuity of the deprived infants, as measured by the preferential looking method, was reduced by one-fourth at 4 wk (P <0.05) and by one-half at 8 and 12 wk (P <0.0005) compared with control infants. These results suggest that ω-3 fatty acids may be an essential nutrient, and that 22:6ω3 may have a specific function in the photoreceptor membranes of the retina.

    Original languageEnglish (US)
    Pages (from-to)272-276
    Number of pages5
    JournalJournal of Clinical Investigation
    Volume73
    Issue number1
    StatePublished - 1984

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    Omega-3 Fatty Acids
    Macaca mulatta
    Fatty Acids
    alpha-Linolenic Acid
    Retina
    Parturition
    Diet
    Membranes
    Docosahexaenoic Acids
    Vision Disorders
    Visual Acuity
    Phospholipids
    Mothers
    Lipids
    Food
    Pregnancy
    Control Groups

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. / Neuringer, Martha; Connor, W. E.; Van Petten, C.; Barstad, L.

    In: Journal of Clinical Investigation, Vol. 73, No. 1, 1984, p. 272-276.

    Research output: Contribution to journalArticle

    Neuringer, Martha ; Connor, W. E. ; Van Petten, C. ; Barstad, L. / Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. In: Journal of Clinical Investigation. 1984 ; Vol. 73, No. 1. pp. 272-276.
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