Dietary intake of stearidonic acid-enriched soybean oil increases the omega-3 index

Randomized, double-blind clinical study of efficacy and safety

Shawna L. Lemke, John L. Vicini, Hong Su, Daniel A. Goldstein, Margaret A. Nemeth, Elaine S. Krul, William Harris

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Background: The benefits of omega-3 (n-3) long-chain polyunsaturated fatty acids to heart health are well established. Stearidonic acid (SDA, 18:4n-3) may contribute to these benefits. Objective: The objective was to evaluate the ability of SDA-containing soybean oil to increase the omega-3 index [erythrocyte eicosapentaenoic acid (EPA) + docosahexaenoic acid, as a percentage of total fatty acids] and to affect other cardiovascular disease risk markers compared with EPA and regular soy oil (control). Design: This was a randomized, placebo-controlled, double-blind multicenter study in which 252 overweight subjects were randomly assigned to 1 of 3 treatments for 12 wk: 1 g encapsulated soybean oil/d plus 14.7 g liquid soybean oil/d to be mixed in food (control group), 1 g encapsulated EPA/d plus 14.7 g liquid soybean oil/d (EPA group), and 1 g encapsulated soybean oil/d plus 14.7 g liquid SDA-enriched soybean oil/d, providing 4.2 g SDA (SDA group). Subjects consumed treatment oils in exchange for other oils in their diet. Results: The mean (±SE) baseline omega-3 index was similar between treatments, but after 12 wk of treatment values for this index were 4.15 ± 0.12%, 4.84 ± 0.13%, and 4.69 ± 0.15% for control, EPA, and SDA groups, respectively. Values for the EPA and SDA groups were greater than those for control subjects in the intent-to-treat population (P <0.001 and P = 0.006, respectively). No adverse treatment-related effects of SDA-enriched soybean oil were reported. Conclusions: SDA-enriched soybean oil increased the omega-3 index by raising erythrocyte EPA concentrations. SDA-enriched soybean oil is a land-based n-3 fatty acid that is a sustainable approach to increasing tissue concentrations of long-chain polyunsaturated n-3 fatty acids.

Original languageEnglish (US)
Pages (from-to)766-775
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume92
Issue number4
DOIs
StatePublished - Oct 1 2010
Externally publishedYes

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Soybean Oil
Double-Blind Method
Eicosapentaenoic Acid
Safety
Oils
Erythrocyte Indices
Omega-3 Fatty Acids
Therapeutics
stearidonic acid
Clinical Studies
Docosahexaenoic Acids
Unsaturated Fatty Acids
Multicenter Studies
Cardiovascular Diseases
Fatty Acids
Placebos
Diet
Food
Control Groups

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Medicine(all)

Cite this

Dietary intake of stearidonic acid-enriched soybean oil increases the omega-3 index : Randomized, double-blind clinical study of efficacy and safety. / Lemke, Shawna L.; Vicini, John L.; Su, Hong; Goldstein, Daniel A.; Nemeth, Margaret A.; Krul, Elaine S.; Harris, William.

In: American Journal of Clinical Nutrition, Vol. 92, No. 4, 01.10.2010, p. 766-775.

Research output: Contribution to journalArticle

Lemke, Shawna L. ; Vicini, John L. ; Su, Hong ; Goldstein, Daniel A. ; Nemeth, Margaret A. ; Krul, Elaine S. ; Harris, William. / Dietary intake of stearidonic acid-enriched soybean oil increases the omega-3 index : Randomized, double-blind clinical study of efficacy and safety. In: American Journal of Clinical Nutrition. 2010 ; Vol. 92, No. 4. pp. 766-775.
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abstract = "Background: The benefits of omega-3 (n-3) long-chain polyunsaturated fatty acids to heart health are well established. Stearidonic acid (SDA, 18:4n-3) may contribute to these benefits. Objective: The objective was to evaluate the ability of SDA-containing soybean oil to increase the omega-3 index [erythrocyte eicosapentaenoic acid (EPA) + docosahexaenoic acid, as a percentage of total fatty acids] and to affect other cardiovascular disease risk markers compared with EPA and regular soy oil (control). Design: This was a randomized, placebo-controlled, double-blind multicenter study in which 252 overweight subjects were randomly assigned to 1 of 3 treatments for 12 wk: 1 g encapsulated soybean oil/d plus 14.7 g liquid soybean oil/d to be mixed in food (control group), 1 g encapsulated EPA/d plus 14.7 g liquid soybean oil/d (EPA group), and 1 g encapsulated soybean oil/d plus 14.7 g liquid SDA-enriched soybean oil/d, providing 4.2 g SDA (SDA group). Subjects consumed treatment oils in exchange for other oils in their diet. Results: The mean (±SE) baseline omega-3 index was similar between treatments, but after 12 wk of treatment values for this index were 4.15 ± 0.12{\%}, 4.84 ± 0.13{\%}, and 4.69 ± 0.15{\%} for control, EPA, and SDA groups, respectively. Values for the EPA and SDA groups were greater than those for control subjects in the intent-to-treat population (P <0.001 and P = 0.006, respectively). No adverse treatment-related effects of SDA-enriched soybean oil were reported. Conclusions: SDA-enriched soybean oil increased the omega-3 index by raising erythrocyte EPA concentrations. SDA-enriched soybean oil is a land-based n-3 fatty acid that is a sustainable approach to increasing tissue concentrations of long-chain polyunsaturated n-3 fatty acids.",
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AU - Lemke, Shawna L.

AU - Vicini, John L.

AU - Su, Hong

AU - Goldstein, Daniel A.

AU - Nemeth, Margaret A.

AU - Krul, Elaine S.

AU - Harris, William

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