Dietary copper and copper dependant superoxide dismutase in hepatic prostaglandin synthesis by rat liver homogenates

Kirsten J. Lampi, Melvin M. Mathias, Bruce D. Rengers, Kenneth G.D. Allen

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The influence of dietary copper, Cu2+ additions and Cu/Zn SOD additions on liver homogenate PGE2 and PGF2α production was examined in rats. Dietary copper deficiency significantly decreased both PGE2 and PGF2α synthesis in liver homogenates. Cu2+ additions to 10 μM or 100 μM (final) had no effect on PGE2 or PGF2α synthesis in either deficient or control liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately equal to that of control liver, significantly increased PGE2 and PGF2α synthesis in both control and copper deficient liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately three times that of control liver significantly depressed PGE2 and PGF2α synthesis in copper-deficient liver homogenates. In all cases addition of arachidonic acid (100 μM, final) had no influence on the above listed responses. Both PGE2 and PGF2α production by liver homogenates showed a significant correlation with SOD. Both dietary copper and added Cu/Zn SOD, but not added Cu2+, influence PGE2 and PGF2α production in liver homogenates.

Original languageEnglish (US)
Pages (from-to)1191-1202
Number of pages12
JournalNutrition Research
Volume8
Issue number10
DOIs
StatePublished - Oct 1988

Keywords

  • copper
  • prostaglandins
  • superoxide dismutase

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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