Dietary copper and copper dependant superoxide dismutase in hepatic prostaglandin synthesis by rat liver homogenates

Kirsten Lampi, Melvin M. Mathias, Bruce D. Rengers, Kenneth G D Allen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The influence of dietary copper, Cu2+ additions and Cu/Zn SOD additions on liver homogenate PGE2 and PGF2α production was examined in rats. Dietary copper deficiency significantly decreased both PGE2 and PGF2α synthesis in liver homogenates. Cu2+ additions to 10 μM or 100 μM (final) had no effect on PGE2 or PGF2α synthesis in either deficient or control liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately equal to that of control liver, significantly increased PGE2 and PGF2α synthesis in both control and copper deficient liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately three times that of control liver significantly depressed PGE2 and PGF2α synthesis in copper-deficient liver homogenates. In all cases addition of arachidonic acid (100 μM, final) had no influence on the above listed responses. Both PGE2 and PGF2α production by liver homogenates showed a significant correlation with SOD. Both dietary copper and added Cu/Zn SOD, but not added Cu2+, influence PGE2 and PGF2α production in liver homogenates.

Original languageEnglish (US)
Pages (from-to)1191-1202
Number of pages12
JournalNutrition Research
Volume8
Issue number10
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Dinoprost
Superoxide Dismutase
Prostaglandins
Copper
Dinoprostone
Liver
Arachidonic Acid

Keywords

  • copper
  • prostaglandins
  • superoxide dismutase

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Dietary copper and copper dependant superoxide dismutase in hepatic prostaglandin synthesis by rat liver homogenates. / Lampi, Kirsten; Mathias, Melvin M.; Rengers, Bruce D.; Allen, Kenneth G D.

In: Nutrition Research, Vol. 8, No. 10, 1988, p. 1191-1202.

Research output: Contribution to journalArticle

Lampi, Kirsten ; Mathias, Melvin M. ; Rengers, Bruce D. ; Allen, Kenneth G D. / Dietary copper and copper dependant superoxide dismutase in hepatic prostaglandin synthesis by rat liver homogenates. In: Nutrition Research. 1988 ; Vol. 8, No. 10. pp. 1191-1202.
@article{96d100a8c6054552b677296127cf25f5,
title = "Dietary copper and copper dependant superoxide dismutase in hepatic prostaglandin synthesis by rat liver homogenates",
abstract = "The influence of dietary copper, Cu2+ additions and Cu/Zn SOD additions on liver homogenate PGE2 and PGF2α production was examined in rats. Dietary copper deficiency significantly decreased both PGE2 and PGF2α synthesis in liver homogenates. Cu2+ additions to 10 μM or 100 μM (final) had no effect on PGE2 or PGF2α synthesis in either deficient or control liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately equal to that of control liver, significantly increased PGE2 and PGF2α synthesis in both control and copper deficient liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately three times that of control liver significantly depressed PGE2 and PGF2α synthesis in copper-deficient liver homogenates. In all cases addition of arachidonic acid (100 μM, final) had no influence on the above listed responses. Both PGE2 and PGF2α production by liver homogenates showed a significant correlation with SOD. Both dietary copper and added Cu/Zn SOD, but not added Cu2+, influence PGE2 and PGF2α production in liver homogenates.",
keywords = "copper, prostaglandins, superoxide dismutase",
author = "Kirsten Lampi and Mathias, {Melvin M.} and Rengers, {Bruce D.} and Allen, {Kenneth G D}",
year = "1988",
doi = "10.1016/S0271-5317(88)80120-9",
language = "English (US)",
volume = "8",
pages = "1191--1202",
journal = "Nutrition Research",
issn = "0271-5317",
publisher = "Elsevier Inc.",
number = "10",

}

TY - JOUR

T1 - Dietary copper and copper dependant superoxide dismutase in hepatic prostaglandin synthesis by rat liver homogenates

AU - Lampi, Kirsten

AU - Mathias, Melvin M.

AU - Rengers, Bruce D.

AU - Allen, Kenneth G D

PY - 1988

Y1 - 1988

N2 - The influence of dietary copper, Cu2+ additions and Cu/Zn SOD additions on liver homogenate PGE2 and PGF2α production was examined in rats. Dietary copper deficiency significantly decreased both PGE2 and PGF2α synthesis in liver homogenates. Cu2+ additions to 10 μM or 100 μM (final) had no effect on PGE2 or PGF2α synthesis in either deficient or control liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately equal to that of control liver, significantly increased PGE2 and PGF2α synthesis in both control and copper deficient liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately three times that of control liver significantly depressed PGE2 and PGF2α synthesis in copper-deficient liver homogenates. In all cases addition of arachidonic acid (100 μM, final) had no influence on the above listed responses. Both PGE2 and PGF2α production by liver homogenates showed a significant correlation with SOD. Both dietary copper and added Cu/Zn SOD, but not added Cu2+, influence PGE2 and PGF2α production in liver homogenates.

AB - The influence of dietary copper, Cu2+ additions and Cu/Zn SOD additions on liver homogenate PGE2 and PGF2α production was examined in rats. Dietary copper deficiency significantly decreased both PGE2 and PGF2α synthesis in liver homogenates. Cu2+ additions to 10 μM or 100 μM (final) had no effect on PGE2 or PGF2α synthesis in either deficient or control liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately equal to that of control liver, significantly increased PGE2 and PGF2α synthesis in both control and copper deficient liver homogenates. Addition of purified Cu/Zn SOD to a concentration approximately three times that of control liver significantly depressed PGE2 and PGF2α synthesis in copper-deficient liver homogenates. In all cases addition of arachidonic acid (100 μM, final) had no influence on the above listed responses. Both PGE2 and PGF2α production by liver homogenates showed a significant correlation with SOD. Both dietary copper and added Cu/Zn SOD, but not added Cu2+, influence PGE2 and PGF2α production in liver homogenates.

KW - copper

KW - prostaglandins

KW - superoxide dismutase

UR - http://www.scopus.com/inward/record.url?scp=0023812895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023812895&partnerID=8YFLogxK

U2 - 10.1016/S0271-5317(88)80120-9

DO - 10.1016/S0271-5317(88)80120-9

M3 - Article

AN - SCOPUS:0023812895

VL - 8

SP - 1191

EP - 1202

JO - Nutrition Research

JF - Nutrition Research

SN - 0271-5317

IS - 10

ER -