Dietary amino acid-induced systemic lupus erythematosus

Anthony Montanaro, E. J. Bardana

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The effects of dietary manipulations on autoimmune disease are understood poorly. In this article, we detail our experience with a human subject who developed autoimmune hemolytic anemia while participating in a research study that required the ingestion of alfalfa seeds. Subsequent experimentalstudies in primates ingesting alfalfa sprout seeds and L-canavanine (a prominent amino acid constituent of alfalfa) is presented. The results of these studies indicate a potential toxic and immunoregulatory role of L-canavanine in the induction of a systemic lupus-like disease in primates.

Original languageEnglish (US)
Pages (from-to)323-332+x
JournalRheumatic Disease Clinics of North America
Volume17
Issue number2
StatePublished - 1991

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Medicago sativa
Canavanine
Systemic Lupus Erythematosus
Amino Acids
Primate Diseases
Seeds
Autoimmune Hemolytic Anemia
Poisons
Primates
Autoimmune Diseases
Eating
Research

ASJC Scopus subject areas

  • Rheumatology

Cite this

Dietary amino acid-induced systemic lupus erythematosus. / Montanaro, Anthony; Bardana, E. J.

In: Rheumatic Disease Clinics of North America, Vol. 17, No. 2, 1991, p. 323-332+x.

Research output: Contribution to journalArticle

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