Diet-brain connections

Role of neurotoxicants

L. G. Costa, Marina Guizzetti, A. Vitalone

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In certain cases, the consumption of food or beverages can lead to intoxication and disease. Such food-induced intoxications may be due to microbial toxins, to toxic substances naturally occurring in some foods, or to contaminants or residues of various kinds. Some of these agents have neurotoxic properties and may contribute to the etiology of certain psychiatric disorders or neurodegenerative diseases. This paper reviews a selected number of dietary neurotoxicants that naturally, or as a result of human interventions, find their way into food or beverages, and have been associated with neurotoxic outcomes in humans. Chosen examples include domoic acid, a phycotoxin associated with amnesic shellfish poisoning; β-N-oxalylamine-l-alanine (l-BOAA), present in chickling peas and believed to be responsible for neurolathyrism; and two alcohols, methanol and ethanol, which can cause severe neurotoxic effects in adults and the developing fetus.

Original languageEnglish (US)
Pages (from-to)395-400
Number of pages6
JournalEnvironmental Toxicology and Pharmacology
Volume19
Issue number3
DOIs
StatePublished - May 2005
Externally publishedYes

Fingerprint

Food and Beverages
Nutrition
Brain
Lathyrism
Shellfish Poisoning
Diet
Food
Beverages
Poisons
Peas
Neurodegenerative Diseases
Alanine
Psychiatry
Methanol
Fetus
Ethanol
Alcohols
Neurodegenerative diseases
Shellfish
Impurities

Keywords

  • β-N-oxalylamine-l-alanine
  • Domoic acid
  • Ethanol
  • Methanol
  • Neurotoxicants

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Pharmacology

Cite this

Diet-brain connections : Role of neurotoxicants. / Costa, L. G.; Guizzetti, Marina; Vitalone, A.

In: Environmental Toxicology and Pharmacology, Vol. 19, No. 3, 05.2005, p. 395-400.

Research output: Contribution to journalArticle

Costa, L. G. ; Guizzetti, Marina ; Vitalone, A. / Diet-brain connections : Role of neurotoxicants. In: Environmental Toxicology and Pharmacology. 2005 ; Vol. 19, No. 3. pp. 395-400.
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