Diet-brain connections: Role of neurotoxicants

L. G. Costa; M. Guizzetti; A. Vitalone

doi:10.1016/j.etap.2004.12.001

Diet-brain connections: Role of neurotoxicants

L. G. Costa, M. Guizzetti, A. Vitalone

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In certain cases, the consumption of food or beverages can lead to intoxication and disease. Such food-induced intoxications may be due to microbial toxins, to toxic substances naturally occurring in some foods, or to contaminants or residues of various kinds. Some of these agents have neurotoxic properties and may contribute to the etiology of certain psychiatric disorders or neurodegenerative diseases. This paper reviews a selected number of dietary neurotoxicants that naturally, or as a result of human interventions, find their way into food or beverages, and have been associated with neurotoxic outcomes in humans. Chosen examples include domoic acid, a phycotoxin associated with amnesic shellfish poisoning; β-N-oxalylamine-l-alanine (l-BOAA), present in chickling peas and believed to be responsible for neurolathyrism; and two alcohols, methanol and ethanol, which can cause severe neurotoxic effects in adults and the developing fetus.

Original language	English (US)
Pages (from-to)	395-400
Number of pages	6
Journal	Environmental Toxicology and Pharmacology
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/j.etap.2004.12.001
State	Published - May 2005
Externally published	Yes

Keywords

Domoic acid
Ethanol
Methanol
Neurotoxicants
β-N-oxalylamine-l-alanine

ASJC Scopus subject areas

Toxicology
Pharmacology
Health, Toxicology and Mutagenesis

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10.1016/j.etap.2004.12.001

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title = "Diet-brain connections: Role of neurotoxicants",

abstract = "In certain cases, the consumption of food or beverages can lead to intoxication and disease. Such food-induced intoxications may be due to microbial toxins, to toxic substances naturally occurring in some foods, or to contaminants or residues of various kinds. Some of these agents have neurotoxic properties and may contribute to the etiology of certain psychiatric disorders or neurodegenerative diseases. This paper reviews a selected number of dietary neurotoxicants that naturally, or as a result of human interventions, find their way into food or beverages, and have been associated with neurotoxic outcomes in humans. Chosen examples include domoic acid, a phycotoxin associated with amnesic shellfish poisoning; β-N-oxalylamine-l-alanine (l-BOAA), present in chickling peas and believed to be responsible for neurolathyrism; and two alcohols, methanol and ethanol, which can cause severe neurotoxic effects in adults and the developing fetus.",

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T2 - Role of neurotoxicants

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AU - Guizzetti, M.

AU - Vitalone, A.

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AB - In certain cases, the consumption of food or beverages can lead to intoxication and disease. Such food-induced intoxications may be due to microbial toxins, to toxic substances naturally occurring in some foods, or to contaminants or residues of various kinds. Some of these agents have neurotoxic properties and may contribute to the etiology of certain psychiatric disorders or neurodegenerative diseases. This paper reviews a selected number of dietary neurotoxicants that naturally, or as a result of human interventions, find their way into food or beverages, and have been associated with neurotoxic outcomes in humans. Chosen examples include domoic acid, a phycotoxin associated with amnesic shellfish poisoning; β-N-oxalylamine-l-alanine (l-BOAA), present in chickling peas and believed to be responsible for neurolathyrism; and two alcohols, methanol and ethanol, which can cause severe neurotoxic effects in adults and the developing fetus.

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KW - β-N-oxalylamine-l-alanine

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Diet-brain connections: Role of neurotoxicants

Abstract

Keywords

ASJC Scopus subject areas

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