TY - JOUR
T1 - Diastolic dysfunction and autonomic abnormalities in patients with systolic heart failure
AU - Stein, Phyllis K.
AU - Tereshchenko, Larisa
AU - Domitrovich, Peter P.
AU - Kleiger, Robert E.
AU - Perez, Alfonso
AU - Deedwania, Prakash
PY - 2007/4
Y1 - 2007/4
N2 - Background: Patients with systolic heart failure (SHF) often have concomitant diastolic dysfunction (DD). SHF is associated with decreased heart rate variability (HRV), but the impact of degree of DD on HRV in SHF is unclear. Methods and results: HRV was measured in 139 patients, aged 64 ± 12 years, 74% male, LVEF 30 ± 8%. Patients had stable NYHA class II-III CHF on ACE inhibitors or ATII receptor blockers, with LVEF ≤ 40% and BNP ≥ 200 pg/ml. Subjects underwent 2-D echocardiography with Doppler assessment and 24-h Holters. Patients were categorized as having impaired relaxation (E-deceleration time > 2 SD above age-adjusted normal values (AANV), E/A ≤ 1, systolic/diastolic pulmonary vein flow ≥ 1; N = 30), pseudonormal (E-deceleration time within 2 SD of AANV, E/A = 1-2, systolic/diastolic pulmonary vein flow < 1; N = 25) or restrictive filling patterns (E-deceleration time > 2 SD below AANV or/and E/A ratio ≥ 2; N = 84) Differences were adjusted for clinical covariates using UNIANOVA, p < 0.05. HRV was reduced and BNP higher in pseudonormal patients compared to impaired relaxation, but this difference was only significant for restrictive vs. impaired filling. Differences remained significant after adjustment for covariates. Conclusion: Significantly more abnormal HRV, reflecting greater cardiac autonomic dysfunction, is associated with restrictive DD compared to impaired relaxation.
AB - Background: Patients with systolic heart failure (SHF) often have concomitant diastolic dysfunction (DD). SHF is associated with decreased heart rate variability (HRV), but the impact of degree of DD on HRV in SHF is unclear. Methods and results: HRV was measured in 139 patients, aged 64 ± 12 years, 74% male, LVEF 30 ± 8%. Patients had stable NYHA class II-III CHF on ACE inhibitors or ATII receptor blockers, with LVEF ≤ 40% and BNP ≥ 200 pg/ml. Subjects underwent 2-D echocardiography with Doppler assessment and 24-h Holters. Patients were categorized as having impaired relaxation (E-deceleration time > 2 SD above age-adjusted normal values (AANV), E/A ≤ 1, systolic/diastolic pulmonary vein flow ≥ 1; N = 30), pseudonormal (E-deceleration time within 2 SD of AANV, E/A = 1-2, systolic/diastolic pulmonary vein flow < 1; N = 25) or restrictive filling patterns (E-deceleration time > 2 SD below AANV or/and E/A ratio ≥ 2; N = 84) Differences were adjusted for clinical covariates using UNIANOVA, p < 0.05. HRV was reduced and BNP higher in pseudonormal patients compared to impaired relaxation, but this difference was only significant for restrictive vs. impaired filling. Differences remained significant after adjustment for covariates. Conclusion: Significantly more abnormal HRV, reflecting greater cardiac autonomic dysfunction, is associated with restrictive DD compared to impaired relaxation.
KW - Congestive heart failure
KW - Diastolic dysfunction
KW - Heart rate variability
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U2 - 10.1016/j.ejheart.2006.09.013
DO - 10.1016/j.ejheart.2006.09.013
M3 - Article
C2 - 17123863
AN - SCOPUS:33947313996
SN - 1388-9842
VL - 9
SP - 364
EP - 369
JO - European Journal of Heart Failure
JF - European Journal of Heart Failure
IS - 4
ER -