Diagnostic pitfalls in syringocystadenocarcinoma papilliferum: Case report and review of the literature

Nicky Leeborg, Michele Thompson, Sarah Rossmiller, Neil Gross, Clifton White, Ken Gatter

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


We report the first case, to our knowledge, of syringocystadenocarcinoma papilliferum with p63-verified squamous differentiation and extensive dermal invasion accompanying in situ components. An 86-year-old woman presented with a neoplasm on the neck, and the intralesional heterogeneity typical of these neoplasms led to an initial diagnosis on needle biopsy favoring squamous cell carcinoma. Excision illustrated diverse morphology, raising a broad differential diagnosis, including more common extracutaneous malignancies, such as breast, gastrointestinal, and ovarian primary tumors. Fortuitous sectioning revealed a focal connection to the skin surface with evidence of apocrine differentiation allowing final diagnosis as syringocystadenocarcinoma papilliferum. Our literature review shows the histologic and immunohisto-chemical features of syringocystadenocarcinoma papilliferum are not well defined outside of their clear morphologic overlap with syringocystadenoma papilliferum. We describe our findings and diagnostic pitfalls to help pathologists encountering this unusual apocrine neoplasm.

Original languageEnglish (US)
Pages (from-to)1205-1209
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Issue number8
StatePublished - Aug 1 2010

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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