TY - JOUR
T1 - Diagnosis of gastrointestinal stromal tumors
T2 - A consensus approach
AU - Fletcher, Christopher D.M.
AU - Berman, Jules J.
AU - Corless, Christopher
AU - Gorstein, Fred
AU - Lasota, Jerzy
AU - Longley, B. Jack
AU - Miettinen, Markku
AU - O'Leary, Timothy J.
AU - Remotti, Helen
AU - Rubin, Brian P.
AU - Shmookler, Barry
AU - Sobin, Leslie H.
AU - Weiss, Sharon W.
PY - 2002
Y1 - 2002
N2 - As a result of major recent advances in understanding the biology of gastrointestinal stromal tumors (GIST), specifically recognition of the central role of activating KIT mutations and associated KIT protein expression in these lesions, and the development of novel and effective therapy for GISTs using the receptor tyrosine kinase inhibitor STI-571, these tumors have become the focus of considerable attention among pathologists, clinicians, and patients. Stromal/mesenchymal tumors of the gastrointestinal tract have long been a source of confusion and controversy with regard to classification, line(s) of differentiation, and prognostication. Characterization of the KIT pathway and its phenotypic implications has helped to resolve some but not all of these issues. Given the now critical role of accurate and reproducible pathologic diagnosis in ensuring appropriate treatment for patients with GIST, the National Institutes of Health (NIH) convened a GIST workshop in April 2001 with the goal of developing a consensus approach to diagnosis and morphologic prognostication. Key elements of the consensus, as described herein, are the defining role of KIT immunopositivity in diagnosis and a proposed scheme for estimating metastatic risk in these lesions, based on tumor size and mitotic count, recognizing that it is probably unwise to use the definitive term benign for any GIST, at least at the present time.
AB - As a result of major recent advances in understanding the biology of gastrointestinal stromal tumors (GIST), specifically recognition of the central role of activating KIT mutations and associated KIT protein expression in these lesions, and the development of novel and effective therapy for GISTs using the receptor tyrosine kinase inhibitor STI-571, these tumors have become the focus of considerable attention among pathologists, clinicians, and patients. Stromal/mesenchymal tumors of the gastrointestinal tract have long been a source of confusion and controversy with regard to classification, line(s) of differentiation, and prognostication. Characterization of the KIT pathway and its phenotypic implications has helped to resolve some but not all of these issues. Given the now critical role of accurate and reproducible pathologic diagnosis in ensuring appropriate treatment for patients with GIST, the National Institutes of Health (NIH) convened a GIST workshop in April 2001 with the goal of developing a consensus approach to diagnosis and morphologic prognostication. Key elements of the consensus, as described herein, are the defining role of KIT immunopositivity in diagnosis and a proposed scheme for estimating metastatic risk in these lesions, based on tumor size and mitotic count, recognizing that it is probably unwise to use the definitive term benign for any GIST, at least at the present time.
KW - CD117
KW - Diagnosis
KW - GIST
KW - Gastrointestinal stromal tumor
KW - Guidelines
KW - KIT
KW - Sarcoma
UR - http://www.scopus.com/inward/record.url?scp=0036081738&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036081738&partnerID=8YFLogxK
U2 - 10.1177/106689690201000201
DO - 10.1177/106689690201000201
M3 - Article
C2 - 12075401
AN - SCOPUS:0036081738
SN - 1066-8969
VL - 10
SP - 81
EP - 89
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
IS - 2
ER -