Diagnosis

Atypical fibroxanthoma or not? Evaluating spindle cell malignancies on sun damaged skin: A practical approach

P. W. Heintz, Clifton White

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Poorly differentiated spindle cell malignancies on sun damaged skin frequently pose a diagnostic challenge for dermatopathologists. The vast majority of these neoplasms ultimately are diagnosed as either atypical fibroxanthoma (AFX), spindle cell squamous cell carcinoma (SCSCC), or spindle cell melanoma (SCM), and rarely leiomyosarcoma or angiosarcoma. Light microscopic clues may suggest one of these neoplasms, but subtle and overlapping characteristics often render precise diagnosis impossible based on morphological features alone. Immunohistochemistry therefore is necessary to firmly and accurately diagnose the majority of spindle cell malignancies on sun damaged skin. We summarize typical clinical and histological findings associated with this group of malignancies and offer a practical immunohistochemical approach to use in their diagnosis.

Original languageEnglish (US)
Pages (from-to)78-83
Number of pages6
JournalSeminars in Cutaneous Medicine and Surgery
Volume18
Issue number1
StatePublished - 1999

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Solar System
Skin
Neoplasms
Hemangiosarcoma
Leiomyosarcoma
Squamous Cell Carcinoma
Melanoma
Immunohistochemistry
Light

ASJC Scopus subject areas

  • Dermatology

Cite this

Diagnosis : Atypical fibroxanthoma or not? Evaluating spindle cell malignancies on sun damaged skin: A practical approach. / Heintz, P. W.; White, Clifton.

In: Seminars in Cutaneous Medicine and Surgery, Vol. 18, No. 1, 1999, p. 78-83.

Research output: Contribution to journalArticle

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