Diagnosis and treatment of obstructive sleep apnea of the larynx

M. B. Gillespie, Paul Flint, P. L. Smith, D. W. Eisele, A. R. Schwartz

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

To determine the mechanism for obstructive sleep apnea in two patients with clinical abnormalities of laryngeal function, airflow dynamics during sleep were analyzed. The site of airway obstruction was assessed by examining pressure gradients across specific airway segments. The relation between maximal inspiratory airflow and nasal pressure was analyzed to determine (1) the critical pressure, a measure of the collapsibility of the laryngeal airway, and (2) the effect of nasal continuous positive airway pressure on airflow during sleep. Large inspiratory pressure gradients developed during sleep between the supraglottic and pleural spaces, indicating that collapse had occurred in the larynx. Elevated critical pressures of -6.4 and +1.2 cm H2O, respectively, occurred in the two patients. When the nasal pressure was raised to 10 cm H2O, normal levels of tidal airflow occurred, and obstructive apneas were eliminated. These findings indicate that sleep apnea was caused by laryngeal airflow obstruction that resulted from elevations in the collapsibility of the larynx. The response to nasal continuous positive airway pressure suggested that laryngeal sleep apnea was similar to pharyngeal sleep apnea in pathophysiologic characteristic and response to treatment.

Original languageEnglish (US)
Pages (from-to)335-339
Number of pages5
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume121
Issue number3
StatePublished - 1995
Externally publishedYes

Fingerprint

Obstructive Sleep Apnea
Larynx
Pressure
Sleep Apnea Syndromes
Sleep
Continuous Positive Airway Pressure
Nose
Therapeutics
Apnea
Airway Obstruction

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Gillespie, M. B., Flint, P., Smith, P. L., Eisele, D. W., & Schwartz, A. R. (1995). Diagnosis and treatment of obstructive sleep apnea of the larynx. Archives of Otolaryngology - Head and Neck Surgery, 121(3), 335-339.

Diagnosis and treatment of obstructive sleep apnea of the larynx. / Gillespie, M. B.; Flint, Paul; Smith, P. L.; Eisele, D. W.; Schwartz, A. R.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 121, No. 3, 1995, p. 335-339.

Research output: Contribution to journalArticle

Gillespie, MB, Flint, P, Smith, PL, Eisele, DW & Schwartz, AR 1995, 'Diagnosis and treatment of obstructive sleep apnea of the larynx', Archives of Otolaryngology - Head and Neck Surgery, vol. 121, no. 3, pp. 335-339.
Gillespie, M. B. ; Flint, Paul ; Smith, P. L. ; Eisele, D. W. ; Schwartz, A. R. / Diagnosis and treatment of obstructive sleep apnea of the larynx. In: Archives of Otolaryngology - Head and Neck Surgery. 1995 ; Vol. 121, No. 3. pp. 335-339.
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