Diacylglycerols: Biomarkers of a sustained immune response in proteinopathies

Paul L. Wood, Randall J. Woltjer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Proteinopathies, associated with the development of dementia, are characterized by both systemic inflammation and neuroinflammation. This sustained/unresolved immune response involves a large number of inflammatory mediators that ultimately may be responsible for the neuronal deficits that underlie cognitive dysfunction. Our research and that of others have demonstrated elevated levels of diacylglycerols in the brain and plasma of patients with proteinopathies. We conclude that these metabolic products of phospholipases C and D are lipid biomarkers of unresolved immune pathology. Since diacylglycerols serve both structural and signal transduction roles, elevations in the levels of these normally tightly regulated lipids may contribute to neuronal dysfunction in proteinopathies.

Original languageEnglish (US)
Title of host publicationDiagnosis and Management in Dementia
Subtitle of host publicationThe Neuroscience of Dementia, Volume 1
PublisherElsevier
Pages255-262
Number of pages8
ISBN (Electronic)9780128158548
DOIs
StatePublished - Jan 1 2020

Keywords

  • Alzheimer’s disease
  • Diacylglycerols
  • Lewy body disease
  • Neuroinflammation
  • Parkinson’s disease

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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